UBE2H and NEURL1

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2H	NEURL1
Gene Name		ubiquitin-conjugating enzyme E2H	neuralized E3 ubiquitin protein ligase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Postsynaptic Density Cell Junction Dendritic Spine Perikaryon Postsynaptic Membrane Perinuclear Region Of Cytoplasm Apical Dendrite
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Translation Factor Activity, Non-nucleic Acid Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Regulation Of Translation Protein Monoubiquitination Notch Signaling Pathway Sperm Axoneme Assembly Nervous System Development Lactation Negative Regulation Of Cell Proliferation Sperm Motility Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Cellular Response To Amino Acid Stimulus Positive Regulation Of Synapse Maturation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		57 interactors: BRAP BYSL CBLC CD99 DTX3 DTX3L DZIP3 EPS15 HDAC6 HIST2H2AA3 JADE1 LRSAM1 MARCH1 MARCH10 MARCH2 MARCH4 MARCH8 MKRN3 NEURL1 NHLRC1 POLL POLM RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 UBA1 UBASH3B UBOX5 UBR2	3 interactors: UBE2D1 UBE2H UBE2N
Entrez ID		7328	9148
HPRD ID		03052	04815
Ensembl ID		ENSG00000186591	ENSG00000107954
Uniprot IDs		A4D1L5 P62256	B4DS86 O76050
PDB IDs		2Z5D
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Protein Catabolic Process Histone Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Regulation Of Viral Entry Into Host Cell Cellular Macromolecule Catabolic Process Cellular Process Negative Regulation Of Protein Metabolic Process Histone Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Viral Process Regulation Of ERBB Signaling Pathway Protein Trimerization Aggresome Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K6-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromatin Modification Negative Regulation Of Cellular Protein Metabolic Process Proteolysis Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Negative Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Proteolysis Regulation Of Innate Immune Response Catabolic Process Regulation Of Histone Ubiquitination DNA Double-strand Break Processing Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Immune Response Cellular Protein Modification Process Postreplication Repair Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Innate Immune Response Regulation Of Immune Response Protein K63-linked Ubiquitination Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Mitotic Spindle Assembly Checkpoint DNA Catabolic Process, Exonucleolytic Regulation Of Organelle Organization Histone Ubiquitination Positive Regulation Of DNA Repair Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Chromosome Segregation Spindle Checkpoint
Tagcloud ?		0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Difference) ?		0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1
Tagcloud (Intersection) ?