UBE2H and MARCHF4

Number of citations of the paper that reports this interaction (PubMedID 14722266)
36

Data Source:
BioGRID (pull down)

		UBE2H	MARCHF4
Description		ubiquitin conjugating enzyme E2 H	membrane associated ring-CH-type finger 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Golgi Membrane Golgi Apparatus Golgi Stack Trans-Golgi Network Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	4 interacting genes: CD4 UBC UBE2D1 UBE2H
Entrez ID		7328	57574
HPRD ID		03052	16299
Ensembl ID		ENSG00000186591	ENSG00000144583
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9P2E8
PDB IDs		2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Response To Methamphetamine Hydrochloride Post-translational Protein Modification Macromolecule Catabolic Process Immunoglobulin Binding MHC Class II Protein Binding Cellular Response To Ionomycin Proteolysis Ubiquitin-protein Transferase Activity Protein Polyubiquitination Interleukin-15-mediated Signaling Pathway Positive Regulation Of Monocyte Differentiation Cellular Response To Ether Positive Regulation Of Protein Modification Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Viral Entry Into Host Cell Protein Modification Process Protein Tag Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Monocyte Differentiation T Cell Receptor Complex Proteasomal Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Regulation Of Viral Entry Into Host Cell Response To Ether Catabolic Process Positive Regulation Of Viral Life Cycle MHC Class II Protein Complex Binding Ubiquitin-dependent Protein Catabolic Process Response To Vitamin D T Cell Selection Regulation Of Protein Polyubiquitination
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