UBE2H and RNF103

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2H	RNF103
Description		ubiquitin conjugating enzyme E2 H	ring finger protein 103
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Central Nervous System Development Protein Ubiquitination ERAD Pathway Endoplasmic Reticulum Mannose Trimming
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Number of sexual partners ( 30643258)
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	11 interacting genes: UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2H UBE2L3 UBE2N UBE2W UBE2Z
Entrez ID		7328	7844
HPRD ID		03052	03939
Ensembl ID		ENSG00000186591	ENSG00000239305
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	O00237
PDB IDs		2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process ATP Binding Protein Modification Process Macromolecule Catabolic Process Nucleotide Binding Transferase Activity Proteolysis Protein Monoubiquitination Catabolic Process Protein Metabolic Process Macromolecule Metabolic Process ISG15 Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Proteasomal Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Nucleus TOR Signaling Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of TOR Signaling Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Protein Ubiquitination Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Protein Targeting To Mitochondrion Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Nucleoplasm Negative Regulation Of BMP Signaling Pathway Ubiquitin Protein Ligase Binding
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