UBE2H and RNF186

Number of citations of the paper that reports this interaction (PubMedID 33280498)
58

Data Source:
BioGRID (pull down)

		UBE2H	RNF186
Description		ubiquitin conjugating enzyme E2 H	ring finger protein 186
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Ubiquitination Protein K29-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Apoptotic Process In Response To Mitochondrial Fragmentation Regulation Of Autophagosome Assembly
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 20228799 23511034 28067908)
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	8 interacting genes: EPHB2 EPHB3 HIVEP1 PBX3 SCAND1 SESN2 UBE2D2 UBE2H
Entrez ID		7328	54546
HPRD ID		03052	07885
Ensembl ID		ENSG00000186591	ENSG00000178828
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9NXI6
PDB IDs		2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	Axon Guidance Receptor Activity Urogenital System Development Corpus Callosum Development Dendritic Spine Development Retinal Ganglion Cell Axon Guidance Transmembrane-ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Dendritic Spine Morphogenesis Ephrin Receptor Activity Central Nervous System Projection Neuron Axonogenesis Dendritic Spine Organization Central Nervous System Neuron Axonogenesis Ubiquitin Conjugating Enzyme Activity Neuron Projection Organization Postsynapse Organization Neuron Recognition Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Polyubiquitination Protein Modification Process Positive Regulation Of Synapse Assembly Posterior Compartment Specification Anterior Compartment Pattern Formation Roof Of Mouth Development Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Sulfiredoxin Activity Positive Regulation Of Cell Junction Assembly Protein K48-linked Ubiquitination Vesicle-mediated Intercellular Transport Cell Recognition Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Tyrosine Kinase Activity Regulation Of Axonogenesis Compartment Pattern Specification ATP Binding Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Axonogenesis Dorsal Spinal Cord Development Protein Ubiquitination Positive Regulation Of Lipophagy Regulation Of Synapse Assembly Enzyme-linked Receptor Protein Signaling Pathway Oxidoreductase Activity, Acting On Peroxide As Acceptor Protein Modification By Small Protein Conjugation Postsynaptic Membrane Assembly L-leucine Binding Atg1/ULK1 Kinase Complex
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