UBE2H and RNF139

Number of citations: 29 (PubMedID 19549727)
Data Source: BioGRID (two hybrid)

		UBE2H	RNF139
Name		ubiquitin conjugating enzyme E2 H	ring finger protein 139
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Destabilization ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	ER Quality Control Compartment (ERQC)
GWAS		Estimated glomerular filtration rate ( 31152163 31451708 ) Lymphocyte count ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Response to antidepressants and depression ( 27622933 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	7 interacting genes: CFTR COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		7328	11236
HPRD ID		03052	04333
Ensembl ID		ENSG00000186591	ENSG00000170881
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q8WU17
PDB IDs		2Z5D 8PJN	Not available
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Eukaryotic Translation Initiation Factor 3 Complex Ubiquitin-dependent Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Protein Ubiquitination ATP Binding Proteolysis Involved In Protein Catabolic Process Translation Initiation Factor Activity Protein Modification Process Nucleotide Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Translational Initiation Enzyme Binding Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Anion Channel Activity Macromolecule Catabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Macrophage Migration Inhibitory Factor Binding Proteasomal Protein Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Monoatomic Anion Transport Translation Reinitiation Multi-eIF Complex Cytosol Positive Regulation Of Enamel Mineralization Exosomal Secretion Transepithelial Water Transport Protein Catabolic Process Viral Translational Termination-reinitiation HULC Complex Cellular Response To Ionomycin Positive Regulation Of Tooth Mineralization DeNEDDylase Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Molecular Adaptor Activity Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transcription Elongation Factor Activity