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UBE2H and HIST2H2AA3
Number of citations of the paper that reports this interaction (PMID
8543049
)
5
Data Source:
HPRD
(in vitro)
UBE2H
HIST2H2AA3
Gene Name
ubiquitin-conjugating enzyme E2H
histone cluster 2, H2aa3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Biological_process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
57 interactors:
BRAP
BYSL
CBLC
CD99
DTX3
DTX3L
DZIP3
EPS15
HDAC6
HIST2H2AA3
JADE1
LRSAM1
MARCH1
MARCH10
MARCH2
MARCH4
MARCH8
MKRN3
NEURL1
NHLRC1
POLL
POLM
RAG1
RELA
RNF10
RNF103
RNF113B
RNF114
RNF128
RNF133
RNF139
RNF144A
RNF146
RNF166
RNF185
RNF186
RNF2
RNF34
RNF38
RNF4
RNF6
STAM2
TRAIP
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM28
TRIM36
TRIM37
TRIM5
TRIM56
UBA1
UBASH3B
UBOX5
UBR2
16 interactors:
APP
BAP1
BMI1
DNAJC2
IL33
MSL2
NOC2L
PARP1
PRMT6
RCC1
RNF2
RNF20
TBL1X
UBE2H
USP16
USP21
Entrez ID
7328
8337
HPRD ID
03052
08851
Ensembl ID
ENSG00000186591
Uniprot IDs
A4D1L5
P62256
Q6FI13
PDB IDs
2Z5D
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Protein Autoubiquitination
Cellular Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Monoubiquitination
Regulation Of Viral Release From Host Cell
Metabolic Process
Histone Ubiquitination
Protein Catabolic Process
Histone Monoubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Negative Regulation Of Viral Process
Protein K63-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Regulation Of Viral Entry Into Host Cell
Cellular Macromolecule Catabolic Process
Cellular Process
Negative Regulation Of Protein Metabolic Process
Histone Modification
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Viral Process
Regulation Of ERBB Signaling Pathway
Protein Trimerization
Aggresome Assembly
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein K6-linked Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Histone H2A Monoubiquitination
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Chromatin Modification
Negative Regulation Of Cellular Protein Metabolic Process
Proteolysis
Catabolic Process
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Negative Regulation Of Viral Entry Into Host Cell
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Chromosome Organization
Chromatin Organization
Chromatin Modification
Histone Modification
Organelle Organization
Histone Ubiquitination
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
Gene Expression
Regulation Of RNA Metabolic Process
Histone Deubiquitination
Histone Monoubiquitination
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Histone H2A-K119 Monoubiquitination
Protein Metabolic Process
Protein Catabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Monoubiquitinated Histone H2A Deubiquitination
Positive Regulation Of Gene Expression
Macromolecule Biosynthetic Process
Protein Monoubiquitination
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Cellular Macromolecule Catabolic Process
Tagcloud
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0e
1426a
219g
3072g
abhd16a
abhd5
acp2
alms1
apoa2
atp1a2
bft
col14a1
ctsf
dars
decr1
ghrl
intron3
mc4r
mttp
nfkbia
nt5e
pfp
plat
ppp2r5d
rfc2
rragd
sdhd
serpinf1
tbc1d1
Tagcloud (Difference)
?
0e
1426a
219g
3072g
abhd16a
abhd5
acp2
alms1
apoa2
atp1a2
bft
col14a1
ctsf
dars
decr1
ghrl
intron3
mc4r
mttp
nfkbia
nt5e
pfp
plat
ppp2r5d
rfc2
rragd
sdhd
serpinf1
tbc1d1
Tagcloud (Intersection)
?