RAG1 and CAPRIN1

Data Source: HiPPIP (Novel)

		RAG1	CAPRIN1
Name		recombination activating 1	cell cycle associated protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Lamellipodium Dendrite Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Intracellular Membraneless Organelle Synapse
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endonuclease Activity	Nucleotide Binding RNA Binding MRNA Binding Protein Binding ATP Binding Signaling Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Chromatin Organization Immune Response Visual Learning B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Regulation Of Behavioral Fear Response	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Nervous System Development Synapse Assembly Intracellular MRNA Localization Negative Regulation Of Translation Cell Differentiation Stress Granule Assembly Negative Regulation Of Translational Initiation Generation Of Neurons Positive Regulation Of Dendrite Morphogenesis Synapse Organization Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Stress Granule Assembly Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Membraneless Organelle Assembly
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	None
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	None
GWAS		Rheumatoid arthritis ( 24390342 )	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232 ) Major depressive disorder x sex interaction ( 34099189 ) Systolic blood pressure ( 30224653 )
Novel Interactors		5 novel interactors: APOF CAPRIN1 PAX6 SNX6 TBCA	3 novel interactors: RAG1 RAG2 WT1
Interacting Genes		19 interacting genes: APP CDC34 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4C16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 TP53 UBC UBE2C UBE2D1 UBE2D2 UBE2H	10 interacting genes: APP CEBPA DAPK1 EIF2AK2 FXR2 MFHAS1 PIN1 PKNOX1 PRMT1 WBP4
Entrez ID		5896	4076
HPRD ID		01556	03108
Ensembl ID		ENSG00000166349	ENSG00000135387
Uniprot IDs		P15918	Q14444
PDB IDs		Not available	4WBE 4WBP 6TA7 7XHG 8TH7
GO Terms Enriched among Interactors		Chromatin Remodeling Chromatin Organization Ubiquitin Conjugating Enzyme Activity V(D)J Recombination Structural Constituent Of Chromatin Protein Heterodimerization Activity Protein K48-linked Ubiquitination Somatic Cell DNA Recombination Nucleosome Assembly RAGE Receptor Binding Nucleus Nucleosome Nucleoplasm Nucleosome Organization Molecular Function Activator Activity Protein-DNA Complex Assembly Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Chemoattractant Activity Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex Assembly Proteolysis Involved In Protein Catabolic Process Chromosome Supercoiled DNA Binding B Cell Lineage Commitment Protein Modification By Small Protein Conjugation Positive Chemotaxis Epigenetic Regulation Of Gene Expression Protein Polyubiquitination DNA Binding DNA Metabolic Process DNA Geometric Change Protein-containing Complex Cell Activation Involved In Immune Response Protein-containing Complex Organization DNA Topological Change NLS-dependent Protein Nuclear Import Complex Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Chromosome Organization Post-translational Protein Modification Catabolic Process Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Differentiation Regulation Of MiRNA Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle	Regulation Of Translation DNA Recombinase Complex Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Pre-B Cell Allelic Exclusion Negative Regulation Of Translation Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Nucleus Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Regulation Of Hematopoietic Stem Cell Proliferation Mononuclear Cell Differentiation Negative Regulation Of Gene Expression V(D)J Recombination Regulation Of Developmental Process Identical Protein Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Differentiation Positive Regulation Of P38MAPK Cascade T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Chromatin Organization Defense Response Regulation Of Cell Development Regulation Of Hemopoiesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Chromatin Binding Cellular Developmental Process Macromolecule Metabolic Process