RAG1 and TBCA

Data Source: HiPPIP (Novel)

		RAG1	TBCA
Name		recombination activating 1	tubulin folding cofactor A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Nucleolus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endonuclease Activity	RNA Binding Protein Binding Tubulin Binding Beta-tubulin Binding Protein-folding Chaperone Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Chromatin Organization Immune Response Visual Learning B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Regulation Of Behavioral Fear Response	Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Post-chaperonin tubulin folding pathway
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	None
GWAS		Rheumatoid arthritis ( 24390342 )	Appendicular lean mass ( 33097823 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 )
Novel Interactors		5 novel interactors: APOF CAPRIN1 PAX6 SNX6 TBCA	7 novel interactors: AFF1 CNTN4 EDIL3 LHFPL2 PAM PHAX RAG1
Interacting Genes		19 interacting genes: APP CDC34 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4C16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 TP53 UBC UBE2C UBE2D1 UBE2D2 UBE2H	5 interacting genes: CDC42 CEBPA ERBB3 TAF9 TERF2IP
Entrez ID		5896	6902
HPRD ID		01556	18166
Ensembl ID		ENSG00000166349	ENSG00000171530
Uniprot IDs		P15918	E5RIX8 O75347 Q6FGD7
PDB IDs		Not available	1H7C
GO Terms Enriched among Interactors		Chromatin Remodeling Chromatin Organization Ubiquitin Conjugating Enzyme Activity V(D)J Recombination Structural Constituent Of Chromatin Protein Heterodimerization Activity Protein K48-linked Ubiquitination Somatic Cell DNA Recombination Nucleosome Assembly RAGE Receptor Binding Nucleus Nucleosome Nucleoplasm Nucleosome Organization Molecular Function Activator Activity Protein-DNA Complex Assembly Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Chemoattractant Activity Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex Assembly Proteolysis Involved In Protein Catabolic Process Chromosome Supercoiled DNA Binding B Cell Lineage Commitment Protein Modification By Small Protein Conjugation Positive Chemotaxis Epigenetic Regulation Of Gene Expression Protein Polyubiquitination DNA Binding DNA Metabolic Process DNA Geometric Change Protein-containing Complex Cell Activation Involved In Immune Response Protein-containing Complex Organization DNA Topological Change NLS-dependent Protein Nuclear Import Complex Regulation Of Carbohydrate Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Development Chromosome Organization Post-translational Protein Modification Catabolic Process Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Differentiation Regulation Of MiRNA Transcription Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle	None