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PEX19 and STK3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PEX19
STK3
Description
peroxisomal biogenesis factor 19
serine/threonine kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Peroxisome
Peroxisomal Membrane
Cytosol
Membrane
Brush Border Membrane
Protein-containing Complex
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Protein-containing Complex
Molecular Function
Protein Binding
Peroxisome Membrane Targeting Sequence Binding
Peroxisome Membrane Class-1 Targeting Sequence Binding
ATPase Binding
Protein Carrier Chaperone
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
Protein Serine Kinase Activity
Transcription Regulator Activator Activity
Biological Process
Protein Folding
Protein Targeting To Peroxisome
Peroxisome Organization
Peroxisome Membrane Biogenesis
Peroxisome Fission
Protein Import Into Peroxisome Membrane
Protein Stabilization
Establishment Of Protein Localization To Peroxisome
Negative Regulation Of Lipid Binding
Neural Tube Formation
Endocardium Development
Protein Phosphorylation
Protein Import Into Nucleus
Apoptotic Process
Signal Transduction
JNK Cascade
Central Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Organ Growth
Hippo Signaling
Positive Regulation Of Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of JNK Cascade
Negative Regulation Of Organ Growth
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Protein Tetramerization
Centrosome Separation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Canonical Wnt Signaling Pathway
Primitive Hemopoiesis
Cell Differentiation Involved In Embryonic Placenta Development
Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Protein Localization To Centrosome
Negative Regulation Of Canonical Wnt Signaling Pathway
Hepatocyte Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
ABC transporters in lipid homeostasis
Class I peroxisomal membrane protein import
Class I peroxisomal membrane protein import
Signaling by Hippo
Drugs
Fostamatinib
Diseases
Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Depressive symptom improvement (
30468137
)
Heel bone mineral density (
30598549
)
Rosacea symptom severity (
29771307
)
Suicide behavior (
26079190
)
Interacting Genes
39 interacting genes:
ABCD1
ABCD2
ABCD3
BCL2L11
CDC25A
CDKN2A
DLG4
EIF1B
F11R
FKBP7
GSKIP
IFNB1
IL23A
IRF3
KIFAP3
NAT8L
OIP5
PEX10
PEX11A
PEX11B
PEX12
PEX13
PEX14
PEX16
PEX26
PEX3
PMP22
PPIB
PSORS1C2
PXMP4
SLC25A17
SLC34A1
SLC61A1
SMAD2
SRPK1
STK3
SUOX
TMEM54
TXN2
41 interacting genes:
AKT1
CASP3
CDK1
CNKSR1
CPNE1
DDAH2
EIF4EBP1
FAM9B
GABARAP
GABARAPL1
GAD1
GBP2
GMCL1
HSPE1
KEAP1
KHSRP
LATS2
LRRK2
MAP1LC3B
MAP1LC3C
MARK2
MBP
MOB3B
MOB4
MPP1
OGT
ORM2
PEX19
PIN1
QARS1
RAF1
RASSF4
SAV1
SLMAP
SNIP1
SULT2A1
TFPT
TRAF1
TRIM21
TRIM69
ZC3H7A
Entrez ID
5824
6788
HPRD ID
02610
05433
Ensembl ID
ENSG00000162735
ENSG00000104375
Uniprot IDs
A0A0S2Z497
P40855
A0A087WZ06
A0A384MR07
Q13188
PDB IDs
2W85
2WL8
3AJB
3MK4
5LNF
3WWS
4HKD
4L0N
4LG4
4LGD
4OH9
5BRM
5DH3
6AO5
6AR2
8A66
Enriched GO Terms of Interacting Partners
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Peroxisome Organization
Peroxisomal Membrane
Peroxisomal Membrane Transport
Peroxisome
Establishment Of Protein Localization To Peroxisome
Protein Import Into Peroxisome Matrix
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Unfolding
Intracellular Protein Transmembrane Transport
Protein Import Into Peroxisome Matrix, Substrate Release
Receptor Recycling
Peroxisomal Importomer Complex
Protein Transmembrane Transport
Long-chain Fatty Acid Import Into Peroxisome
Receptor Metabolic Process
Protein Import Into Peroxisome Membrane
Very Long-chain Fatty Acid Catabolic Process
Protein Transmembrane Transporter Activity
Establishment Of Protein Localization To Organelle
Fatty Acid Oxidation
Fatty Acid Catabolic Process
Protein Localization To Organelle
Lipid Oxidation
Cellular Localization
Fatty Acyl-CoA Hydrolase Activity
Organophosphate Ester Transmembrane Transporter Activity
Nucleobase-containing Compound Transmembrane Transporter Activity
Cellular Response To Reactive Oxygen Species
Long-chain Fatty Acid Transmembrane Transporter Activity
Fatty Acid Beta-oxidation
Intracellular Transport
Protein Monoubiquitination
Organelle Organization
Sulfur Compound Transmembrane Transporter Activity
Amide Transmembrane Transporter Activity
Regulation Of Peroxisome Size
Peroxisome Membrane Biogenesis
Lipid Modification
Intracellular Protein Transport
Transmembrane Transport
Protein Import Into Peroxisome Matrix, Translocation
Protein Import Into Peroxisome Matrix, Docking
Response To Reactive Oxygen Species
Fatty Acid Transport
Protein-containing Complex
ATPase-coupled Transmembrane Transporter Activity
Protein To Membrane Docking
Very Long-chain Fatty Acid Metabolic Process
Intracellular Lipid Transport
Protein Binding
Cellular Response To Nitrogen Starvation
Autophagy Of Mitochondrion
Phosphatidylethanolamine Binding
Regulation Of Hippo Signaling
Cytoplasm
Mitophagy
Autophagosome
Cellular Response To Nutrient Levels
Autophagosome Assembly
Vacuole Organization
Cellular Response To Starvation
Autophagosome Organization
Regulation Of Intracellular Signal Transduction
Autophagy
Autophagosome Maturation
Positive Regulation Of Proteolysis
Intracellular Signal Transduction
Autophagosome Membrane
Response To Starvation
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cytosol
Protein-containing Complex Disassembly
Negative Regulation Of Hippo Signaling
Hippo Signaling
Apoptotic Process
Macroautophagy
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Programmed Cell Death
Protein Binding
Cell Death
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Organ Growth
Signal Transduction
Protein-containing Complex Organization
Positive Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Response To Nutrient Levels
Response To Stress
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Pyroptotic Inflammatory Response
Regulation Of Protein Metabolic Process
Protein Phosphorylation
Positive Regulation Of Proteasomal Protein Catabolic Process
Protein Serine Kinase Activity
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