PEX19 and PMP22

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PEX19	PMP22
Description		peroxisomal biogenesis factor 19	peripheral myelin protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Protein Binding
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12
Entrez ID		5824	5376
HPRD ID		02610	03059
Ensembl ID		ENSG00000162735	ENSG00000109099
Uniprot IDs		A0A0S2Z497 P40855	A0A2R8Y5L5 A8MU75 Q01453 Q6FH25
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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