PEX19 and ABCD1

Number of citations of the paper that reports this interaction (PubMedID 11883941)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PEX19	ABCD1
Description		peroxisomal biogenesis factor 19	ATP binding cassette subfamily D member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Organophosphate Ester Transmembrane Transporter Activity ABC-type Fatty-acyl-CoA Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Amide Transmembrane Transporter Activity ADP Binding Fatty Acyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity Sulfur Compound Transmembrane Transporter Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Very Long-chain Fatty Acid Metabolic Process Regulation Of Oxidative Phosphorylation Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Peroxisome Organization Organophosphate Ester Transport Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Nucleobase-containing Compound Transport Regulation Of Fatty Acid Metabolic Process Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Amide Transport Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Fatty Acid Derivative Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS			Glycated hemoglobin levels ( 34059833)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	5 interacting genes: ABCD2 ABCD3 PEX19 RPSA SLC27A2
Entrez ID		5824	215
HPRD ID		02610	02300
Ensembl ID		ENSG00000162735	ENSG00000101986
Uniprot IDs		A0A0S2Z497 P40855	P33897
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF	7RR9 7RRA 7SHM 7SHN 7VR1 7VWC 7VX8 7VZB 7X07 7X0T 7X0Z 7X1W 7XEC 7YRQ
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Very Long-chain Fatty Acid Catabolic Process Peroxisomal Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Peroxisomal Membrane Transport Peroxisome Peroxisome Organization Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Long-chain Fatty Acid Import Into Peroxisome Methyl-branched Fatty Acid Metabolic Process Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Monocarboxylic Acid Transport Fatty Acyl-CoA Hydrolase Activity Lipid Modification Bile Acid Biosynthetic Process Carboxylic Acid Catabolic Process ATPase-coupled Transmembrane Transporter Activity Bile Acid Metabolic Process Intracellular Lipid Transport Carboxylic Acid Transport Organic Acid Transport Carboxylic Acid Biosynthetic Process Lipid Catabolic Process ABC-type Transporter Activity Fatty Acid Metabolic Process Lipid Transport Fatty Acid Derivative Biosynthetic Process Organic Anion Transport Intracellular Transport Fatty Acid Derivative Metabolic Process Small Molecule Biosynthetic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Monocarboxylic Acid Metabolic Process Lipid Biosynthetic Process Fatty Acid Biosynthetic Process Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Phytanic Acid Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Organic Acid Transmembrane Transport
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