PEX19 and ABCD3

Number of citations of the paper that reports this interaction (PubMedID 14709540)
35

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		PEX19	ABCD3
Description		peroxisomal biogenesis factor 19	ATP binding cassette subfamily D member 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Lipid Transport Peroxisome Organization Response To Xenobiotic Stimulus Bile Acid And Bile Salt Transport Long-chain Fatty Acid Import Into Peroxisome Very Long-chain Fatty Acid Catabolic Process Transmembrane Transport Phytanic Acid Metabolic Process
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis RHOA GTPase cycle RHOC GTPase cycle Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	7 interacting genes: ABCD1 ABCD2 COL6A2 PEX19 PSMA1 TUFT1 UBC
Entrez ID		5824	5825
HPRD ID		02610	01368
Ensembl ID		ENSG00000162735	ENSG00000117528
Uniprot IDs		A0A0S2Z497 P40855	P28288
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF	8Z0F 8Z9X
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Peroxisomal Membrane Transport Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Peroxisome Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Long-chain Fatty Acid Import Into Peroxisome Fatty Acid Beta-oxidation Peroxisomal Membrane Very Long-chain Fatty Acid Catabolic Process Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Fatty Acid Oxidation Fatty Acyl-CoA Hydrolase Activity Myelin Maintenance Alpha-linolenic Acid Metabolic Process Peroxisome Long-chain Fatty Acid Transmembrane Transporter Activity Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Lipid Modification Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipid Catabolic Process ATPase-coupled Transmembrane Transporter Activity Regulation Of Fatty Acid Oxidation Carboxylic Acid Catabolic Process Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process ABC-type Transporter Activity Regulation Of Reactive Oxygen Species Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Organization Lipid Catabolic Process Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Fatty Acid Biosynthetic Process Long-chain Fatty Acid Transport Fatty Acid Derivative Biosynthetic Process Fatty Acid Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Small Molecule Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process ABC-type Fatty-acyl-CoA Transporter Activity
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