PEX19 and PEX10

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vivo, in vitro)

		PEX19	PEX10
Description		peroxisomal biogenesis factor 19	peroxisomal biogenesis factor 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Peroxisome Peroxisomal Membrane Membrane
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Body mass index ( 26426971) Liver enzyme levels (alkaline phosphatase) ( 33972514) Non-obstructive azoospermia ( 22197933)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	10 interacting genes: CGRRF1 HNRNPD LIG4 MKRN3 PCGF6 PEX12 PEX19 PEX2 PEX5 UBE2I
Entrez ID		5824	5192
HPRD ID		02610	04175
Ensembl ID		ENSG00000162735	ENSG00000157911
Uniprot IDs		A0A0S2Z497 P40855	D6RA89 O60683
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Import Into Peroxisome Matrix Peroxisomal Membrane Pexophagy Peroxisome Membrane Targeting Sequence Binding Receptor Recycling Intracellular Protein Transmembrane Transport Peroxisome Receptor Metabolic Process Protein Monoubiquitination Protein Import Into Peroxisome Membrane Protein Transmembrane Transport Intracellular Protein Transport Protein Carrier Chaperone Lipid Catabolic Process Cellular Response To Reactive Oxygen Species Establishment Of Protein Localization To Organelle Protein Modification By Small Protein Conjugation Intracellular Transport Catabolic Process Protein-containing Complex Disassembly Post-translational Protein Modification Protein Transmembrane Transporter Activity Macroautophagy Response To Reactive Oxygen Species Very Long-chain Fatty Acid Metabolic Process Cellular Localization Establishment Of Localization In Cell Protein Targeting Cellular Response To Oxidative Stress Protein Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine Establishment Of Integrated Proviral Latency Protein Ubiquitination Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Fatty Acid Beta-oxidation SUMO Conjugating Enzyme Activity Protein Localization To Organelle Cellular Response To Chemical Stress Autophagy Establishment Of Protein Localization Circadian Regulation Of Translation
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