PEX19 and PEX3

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PEX19	PEX3
Description		peroxisomal biogenesis factor 19	peroxisomal biogenesis factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Nucleoplasm Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Protein-containing Complex Protein-lipid Complex
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Peroxisome Organization Protein Import Into Peroxisome Membrane
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Skin aging measurement ( 31522824)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	2 interacting genes: PEX16 PEX19
Entrez ID		5824	8504
HPRD ID		02610	04407
Ensembl ID		ENSG00000162735	ENSG00000034693
Uniprot IDs		A0A0S2Z497 P40855	P56589
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF	3AJB 3MK4
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Brush Border Membrane Peroxisomal Membrane Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization Peroxisome Peroxisome Membrane Targeting Sequence Binding Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Protein Targeting Establishment Of Protein Localization To Membrane Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Synaptic Receptor Adaptor Activity Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Protein To Membrane Docking S-shaped Body Morphogenesis Regulation Of Female Gonad Development Metanephric Mesenchyme Development Protein Localization To Membrane Diaphragm Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Establishment Of Protein Localization To Organelle Protein Carrier Chaperone Peroxisome Fission Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Neurofilament Podocyte Differentiation Nephron Tubule Morphogenesis Muscle Cell Fate Commitment C2H2 Zinc Finger Domain Binding Protein Import Into Peroxisome Matrix Metanephric Epithelium Development
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