PEX19 and PEX11A

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PEX19	PEX11A
Description		peroxisomal biogenesis factor 19	peroxisomal biogenesis factor 11 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Peroxisome Peroxisomal Membrane Membrane Protein-containing Complex
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Peroxisome Organization Signal Transduction Peroxisome Membrane Biogenesis Peroxisome Fission Regulation Of Peroxisome Size Brown Fat Cell Differentiation
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	PPARA activates gene expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Height ( 31562340) Two-hour glucose ( 34059833)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	1 interacting genes: PEX19
Entrez ID		5824	8800
HPRD ID		02610	04843
Ensembl ID		ENSG00000162735	ENSG00000166821
Uniprot IDs		A0A0S2Z497 P40855	B2R8C6 B4DMF6 O75192
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Positive Regulation Of Protein Polymerization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Peroxisome Membrane Targeting Sequence Binding Positive Regulation Of Free Ubiquitin Chain Polymerization Peroxisome Membrane Biogenesis Cellular Response To Nutrient Levels Positive Regulation Of Cell Development Anchoring Junction Cellular Response To Vitamin D Focal Adhesion Positive Regulation Of Monocyte Differentiation Regulation Of Protein-containing Complex Assembly Regulation Of Hemopoiesis Protein Targeting To Peroxisome Protein Import Into Peroxisome Membrane Protein Carrier Chaperone Membrane Biogenesis Peroxisome Fission Response To Mitochondrial Depolarisation Myoblast Proliferation Response To Nutrient Levels Immunoglobulin Receptor Binding Positive Regulation Of Cellular Component Biogenesis Organelle Organization Regulation Of Monocyte Differentiation Protein Phosphatase Activator Activity Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Positive Regulation Of Mitophagy Positive Regulation Of Regulatory T Cell Differentiation Cardiac Muscle Cell Proliferation Response To Vitamin D Peroxisome Organization Cul4-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Mast Cell Degranulation Positive Regulation Of Microtubule Polymerization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Cell Adhesion Regulation Of Cell Development Cellular Response To Nutrient GTPase Binding Negative Regulation Of Striated Muscle Cell Apoptotic Process Regulation Of Regulatory T Cell Differentiation Cytoplasmic Vesicle Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Differentiation
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