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STK3 and GBP2
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
STK3
GBP2
Description
serine/threonine kinase 3
guanylate binding protein 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Protein-containing Complex
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
Protein Serine Kinase Activity
Transcription Regulator Activator Activity
Nucleotide Binding
GTPase Activity
Endopeptidase Inhibitor Activity
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein Homodimerization Activity
Molecular Function Inhibitor Activity
Biological Process
Neural Tube Formation
Endocardium Development
Protein Phosphorylation
Protein Import Into Nucleus
Apoptotic Process
Signal Transduction
JNK Cascade
Central Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Organ Growth
Hippo Signaling
Positive Regulation Of Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of JNK Cascade
Negative Regulation Of Organ Growth
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Protein Tetramerization
Centrosome Separation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Canonical Wnt Signaling Pathway
Primitive Hemopoiesis
Cell Differentiation Involved In Embryonic Placenta Development
Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Protein Localization To Centrosome
Negative Regulation Of Canonical Wnt Signaling Pathway
Hepatocyte Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Activation Of Innate Immune Response
Immune System Process
Immune Response
Protein Localization To Nucleus
Defense Response To Bacterium
Defense Response To Protozoan
Innate Immune Response
Symbiont Entry Into Host Cell
Defense Response To Gram-positive Bacterium
Protein Maturation
Defense Response To Virus
Cytolysis In Another Organism
Cellular Response To Lipopolysaccharide
Cellular Response To Type II Interferon
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of AIM2 Inflammasome Complex Assembly
Pathways
Signaling by Hippo
Interferon gamma signaling
Interferon alpha/beta signaling
CASP4 inflammasome assembly
Microbial factors inhibit CASP4 activity
Drugs
Fostamatinib
Diseases
GWAS
Depressive symptom improvement (
30468137
)
Heel bone mineral density (
30598549
)
Rosacea symptom severity (
29771307
)
Suicide behavior (
26079190
)
Serum metabolite levels (
33031748
)
Interacting Genes
41 interacting genes:
AKT1
CASP3
CDK1
CNKSR1
CPNE1
DDAH2
EIF4EBP1
FAM9B
GABARAP
GABARAPL1
GAD1
GBP2
GMCL1
HSPE1
KEAP1
KHSRP
LATS2
LRRK2
MAP1LC3B
MAP1LC3C
MARK2
MBP
MOB3B
MOB4
MPP1
OGT
ORM2
PEX19
PIN1
QARS1
RAF1
RASSF4
SAV1
SLMAP
SNIP1
SULT2A1
TFPT
TRAF1
TRIM21
TRIM69
ZC3H7A
22 interacting genes:
ANXA7
BID
BNIP3L
BTBD2
CSNK2B
FBXO7
FXR1
GADD45A
GSK3B
HSPE1
KLHL20
LSM2
MAGI1
MAPK8IP2
PAFAH1B3
PPP1R8
RPS6KA1
SAT1
SEPHS1
SERPINB9
STK3
TFG
Entrez ID
6788
2634
HPRD ID
05433
02682
Ensembl ID
ENSG00000104375
ENSG00000162645
Uniprot IDs
A0A087WZ06
A0A384MR07
Q13188
P32456
Q8TCE5
PDB IDs
3WWS
4HKD
4L0N
4LG4
4LGD
4OH9
5BRM
5DH3
6AO5
6AR2
8A66
6VKJ
7E58
7M1S
Enriched GO Terms of Interacting Partners
?
Cellular Response To Nitrogen Starvation
Autophagy Of Mitochondrion
Phosphatidylethanolamine Binding
Regulation Of Hippo Signaling
Cytoplasm
Mitophagy
Autophagosome
Cellular Response To Nutrient Levels
Autophagosome Assembly
Vacuole Organization
Cellular Response To Starvation
Autophagosome Organization
Regulation Of Intracellular Signal Transduction
Autophagy
Autophagosome Maturation
Positive Regulation Of Proteolysis
Intracellular Signal Transduction
Autophagosome Membrane
Response To Starvation
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cytosol
Protein-containing Complex Disassembly
Negative Regulation Of Hippo Signaling
Hippo Signaling
Apoptotic Process
Macroautophagy
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Programmed Cell Death
Protein Binding
Cell Death
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Organ Growth
Signal Transduction
Protein-containing Complex Organization
Positive Regulation Of Protein Metabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Response To Nutrient Levels
Response To Stress
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Pyroptotic Inflammatory Response
Regulation Of Protein Metabolic Process
Protein Phosphorylation
Positive Regulation Of Proteasomal Protein Catabolic Process
Protein Serine Kinase Activity
Cytoplasm
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Membrane Permeability
Positive Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrial Membrane Permeability
Mitochondrial Outer Membrane Permeabilization
Positive Regulation Of Intracellular Signal Transduction
Protein Heterodimerization Activity
Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Assembly
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Hepatocyte Apoptotic Process
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Organization
Mitochondrial Membrane Organization
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Catabolic Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Protein Targeting To Mitochondrion
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Proteolysis
Protein Phosphorylation
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of JNK Cascade
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Presynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Microtubule Anchoring At Centrosome
Cytoplasmic Translational Initiation
Ribonuclease E Activity
Spermidine Binding
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Type II Interferon Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Autophagy
Phosphorylation
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