STK3 and MAP1LC3C

Number of citations of the paper that reports this interaction (PubMedID 31857374)
66

Data Source:
BioGRID (pull down)

		STK3	MAP1LC3C
Description		serine/threonine kinase 3	microtubule associated protein 1 light chain 3 gamma
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation
Pathways		Signaling by Hippo	Macroautophagy
Drugs		Fostamatinib
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)
Interacting Genes		41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A	41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24
Entrez ID		6788	440738
HPRD ID		05433	14226
Ensembl ID		ENSG00000104375	ENSG00000197769
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	Q9BXW4
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66	2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity	Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity
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