STK3 and RASSF4

Number of citations of the paper that reports this interaction (PMID 23455922)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		STK3	RASSF4
Gene Name		serine/threonine kinase 3	Ras association (RalGDS/AF-6) domain family member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity	Protein Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Cell Cycle Signal Transduction
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A	3 interactors: HMGB1 MAGEA6 STK3
Entrez ID		6788	83937
HPRD ID		05433	15219
Ensembl ID		ENSG00000104375	ENSG00000107551
Uniprot IDs		B3KYA7 Q13188	Q9H2L5
PDB IDs		4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death	Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Binding Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Binding Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Primitive Hemopoiesis DNA Ligation Involved In DNA Repair Regulation Of Apoptotic Cell Clearance Negative Regulation Of Phagocytosis DNA Ligation Dendritic Cell Chemotaxis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Axon Regeneration Endocardium Development Apoptotic DNA Fragmentation Hepatocyte Apoptotic Process Immune System Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA-templated Transcription, Initiation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Dendritic Cell Migration Myeloid Dendritic Cell Activation Positive Chemotaxis Hippo Signaling V(D)J Recombination Apoptotic Nuclear Changes Embryonic Hemopoiesis Inflammatory Response To Antigenic Stimulus Cell Differentiation Involved In Embryonic Placenta Development DNA Topological Change Positive Regulation Of DNA Binding Negative Regulation Of Organ Growth Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Endocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Metabolic Process Base-excision Repair Regulation Of Phagocytosis
Tagcloud ?		contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1	1b aldefluor aldehyde aldh1 br bright cdna cics cscs cure dehydrogenase elucidate elusive eradication hypothesized initiating knocked maintenance map microarray modulates oral overexpressed proline signal sirna sprr1b suppressed
Tagcloud (Difference) ?		contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1	1b aldefluor aldehyde aldh1 br bright cdna cics cscs cure dehydrogenase elucidate elusive eradication hypothesized initiating knocked maintenance map microarray modulates oral overexpressed proline signal sirna sprr1b suppressed
Tagcloud (Intersection) ?