PEX19 and PEX12

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		PEX19	PEX12
Description		peroxisomal biogenesis factor 19	peroxisomal biogenesis factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Peroxisome Peroxisomal Membrane Cytosol Membrane Peroxisomal Importomer Complex
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Activator Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Targeting To Peroxisome Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		5824	5193
HPRD ID		02610	03455
Ensembl ID		ENSG00000162735	ENSG00000108733
Uniprot IDs		A0A0S2Z497 P40855	O00623
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Membrane Targeting Sequence Binding Endoplasmic Reticulum Membrane Membrane Peroxisome Organization Intracellular Protein Transmembrane Transport Fatty Acid Metabolic Process Endoplasmic Reticulum Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Targeting To Peroxisome Protein Carrier Chaperone Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Monocarboxylic Acid Metabolic Process Protein Transmembrane Transport Pexophagy Triglyceride Catabolic Process Response To Oxidative Stress Cellular Response To Oxidative Stress Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Transmembrane Transporter Activity Receptor Recycling Cellular Response To Reactive Oxygen Species Fatty Acid Biosynthetic Process Acylglycerol Catabolic Process Lipid Catabolic Process Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Membrane Organization Negative Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Ssh1 Translocon Complex 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity
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