PEX19 and SLC34A1

Number of citations of the paper that reports this interaction (PubMedID 14558883)
38

Data Source:
HPRD (two hybrid, in vitro)

		PEX19	SLC34A1
Description		peroxisomal biogenesis factor 19	solute carrier family 34 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Nucleoplasm Endosome Cytosol Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Nuclear Speck Brush Border Membrane Vesicle Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Sodium:phosphate Symporter Activity Protein Binding Symporter Activity PDZ Domain Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Ossification Kidney Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Response To Nutrient Glycoprotein Metabolic Process Response To Xenobiotic Stimulus Response To Lead Ion Cellular Response To Phosphate Starvation Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion Response To Estradiol Response To Vitamin A Phosphate Ion Transmembrane Transport Response To Potassium Ion Indole Metabolic Process Response To Peptide Hormone Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Phosphate Ion Homeostasis Response To Growth Hormone Response To Parathyroid Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Sodium Ion Import Across Plasma Membrane Gentamycin Metabolic Process Response To Peptide Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Activated partial thromboplastin time ( 22703881) Asthma ( 32296059) Calcium levels ( 24068962) Chronic kidney disease ( 31152163 20383146 26831199) Creatinine levels ( 28270201 31015462 29403010) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hematocrit ( 29403010) Inflammatory bowel disease ( 28067908) Kidney stones ( 31729369 26272126) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 29403010) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	11 interacting genes: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 NHERF1 NHERF2 PDZK1 PEX19 YIF1A
Entrez ID		5824	6569
HPRD ID		02610	08918
Ensembl ID		ENSG00000162735	ENSG00000131183
Uniprot IDs		A0A0S2Z497 P40855	Q06495 Q7Z725 Q86VN6
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Brush Border Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Phosphatase Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein Localization To Membrane Apical Plasma Membrane Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Microvillus Membrane Cellular Localization Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Protein Localization To Plasma Membrane ATP-dependent Protein Folding Chaperone Protein Folding Positive Regulation Of Nitric Oxide Biosynthetic Process Localization Within Membrane Positive Regulation Of Nitric Oxide Metabolic Process Intracellular Protein Localization Tau Protein Binding Protein Localization To Cell Periphery Protein Stabilization Cellular Response To Heat CTP Binding DATP Binding Protein Folding Chaperone Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Renal Phosphate Ion Absorption Regulation Of Nitric Oxide Biosynthetic Process Membrane Regulation Of Nitric Oxide Metabolic Process Atrial Cardiac Muscle Cell Development Regulation Of Cell Size Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex PDZ Domain Binding Peroxisome Membrane Targeting Sequence Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?