PEX19 and ABCD2

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		PEX19	ABCD2
Description		peroxisomal biogenesis factor 19	ATP binding cassette subfamily D member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Peroxisome Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity Amide Transmembrane Transporter Activity Protein Heterodimerization Activity Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity Sulfur Compound Transmembrane Transporter Activity
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Peroxisome Organization Response To Bacterium Organophosphate Ester Transport Long-chain Fatty Acid Import Into Peroxisome Nucleobase-containing Compound Transport Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Fatty Acid Beta-oxidation Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Amide Transport Myelin Maintenance Linoleic Acid Metabolic Process Transmembrane Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Fatty Acid Derivative Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	3 interacting genes: ABCD1 ABCD3 PEX19
Entrez ID		5824	225
HPRD ID		02610	03051
Ensembl ID		ENSG00000162735	ENSG00000173208
Uniprot IDs		A0A0S2Z497 P40855	Q9UBJ2
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Peroxisomal Membrane Transport Peroxisome Organization Peroxisomal Membrane Long-chain Fatty Acid Import Into Peroxisome Peroxisome Very Long-chain Fatty Acid Catabolic Process Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acid Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport ABC-type Transporter Activity Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Monocarboxylic Acid Transport Organic Acid Transmembrane Transport ABC-type Fatty-acyl-CoA Transporter Activity Carboxylic Acid Transmembrane Transport Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Lipid Modification Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Intracellular Transport Peroxisome Membrane Targeting Sequence Binding Phytanic Acid Metabolic Process Sulfur Compound Transmembrane Transporter Activity Fatty-acyl-CoA Transport Amide Transmembrane Transporter Activity Carboxylic Acid Catabolic Process Peroxisome Membrane Biogenesis Cellular Localization Carboxylic Acid Transport Organic Acid Transport Carboxylic Acid Biosynthetic Process Lipid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Establishment Of Localization In Cell Fatty-acyl-CoA Catabolic Process Fatty Acid Metabolic Process Lipid Transport
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