PEX19 and PEX14

Number of citations of the paper that reports this interaction (PMID 10704444)
47

Data Source:
BioGRID (two hybrid, biochemical, biochemical)
HPRD (two hybrid, in vivo, in vitro)

		PEX19	PEX14
Gene Name		peroxisomal biogenesis factor 19	peroxisomal biogenesis factor 14
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Integral Component Of Membrane Brush Border Membrane Intracellular Membrane-bounded Organelle Protein Complex	Intracellular Nucleus Nucleolus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Protein Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-terminus Binding ATPase Binding	Transcription Corepressor Activity Receptor Binding Protein Binding Microtubule Binding Protein N-terminus Binding Beta-tubulin Binding
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Transmembrane Transport Chaperone-mediated Protein Folding Chaperone-mediated Protein Transport Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Protein Complex Assembly Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization Negative Regulation Of Protein Homotetramerization
Pathways		ABC-family proteins mediated transport ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS			Breast cancer ( 23535729 23535733) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		32 interactors: ABCD1 ABCD2 ABCD3 CDC25A CDKN2A EIF1B F11R FKBP7 GSKIP IL23A IRF3 KIFAP3 MFSD5 OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PXMP4 SLC25A17 SLC34A1 SMAD2 SRPK1 STK3 TMEM54	8 interactors: HDAC1 MED8 NFE2 PEX19 PEX5 PEX7 SMARCC2 ZHX1
Entrez ID		5824	5195
HPRD ID		02610	03477
Ensembl ID		ENSG00000162735	ENSG00000142655
Uniprot IDs		P40855	F5H4J2 O75381
PDB IDs		2W85 2WL8 3AJB 3MK4	2W84 2W85
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Peroxisomal Membrane Transport Protein Import Peroxisome Membrane Biogenesis Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Protein Import Into Peroxisome Membrane Organelle Organization Protein To Membrane Docking Transmembrane Transport Establishment Of Protein Localization To Organelle Fatty Acid Beta-oxidation Protein Targeting Cellular Lipid Catabolic Process Protein Localization To Organelle Regulation Of Peroxisome Size Lipid Modification Membrane Biogenesis Carboxylic Acid Catabolic Process Protein Import Into Peroxisome Matrix, Docking Very Long-chain Fatty Acid Metabolic Process Lipid Catabolic Process Cytoplasmic Transport Fatty Acid Alpha-oxidation Fatty Acid Metabolic Process Establishment Of Protein Localization Peroxisome Fission Intracellular Transport Protein Localization Cellular Localization Intracellular Protein Transport Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Membrane Cellular Protein Localization Protein Stabilization Membrane Docking Posttranscriptional Regulation Of Gene Expression Protein Transport Positive Regulation Of Viral Genome Replication Cellular Component Assembly Regulation Of Defense Response To Virus By Host Monocarboxylic Acid Metabolic Process	Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Protein Import Into Peroxisome Membrane Peroxisomal Membrane Transport Protein Import Into Peroxisome Matrix Nucleosome Disassembly Protein Import Fatty Acid Beta-oxidation Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process ATP-dependent Chromatin Remodeling Protein Targeting Negative Regulation Of Lipid Binding Transcription, DNA-templated RNA Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Nucleosome Organization Cellular Lipid Catabolic Process Chromatin Assembly Or Disassembly Cellular Metabolic Process Cytoplasmic Transport Organ Development Protein Targeting To Membrane Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Matrix, Docking Neuron Migration Biosynthetic Process Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Lipid Modification Carboxylic Acid Catabolic Process Negative Regulation Of Protein Homooligomerization Ether Lipid Biosynthetic Process Protein Complex Disassembly Central Nervous System Neuron Differentiation Cell Differentiation
Tagcloud ?		amphipathic anchored biogenesis chaperone concerted delivers docking engagement hydrophobic hydrophobicity inserted insertion intercalation moieties peroxisome pex3 promotes prompt reconstitute segment segments sequential steps ta tail tmd translationally uncharacterized unconventional	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex11 pex28 pex3 pex5 pex6 pex7 pex8 pox1 puf5 rbp rfp
Tagcloud (Difference) ?		amphipathic anchored biogenesis chaperone concerted delivers docking engagement hydrophobic hydrophobicity inserted insertion intercalation moieties peroxisome promotes prompt reconstitute segment segments sequential steps ta tail tmd translationally uncharacterized unconventional	aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex11 pex28 pex5 pex6 pex7 pex8 pox1 puf5 rbp rfp
Tagcloud (Intersection) ?		pex3