PEX19 and EIF1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PEX19	EIF1B
Description		peroxisomal biogenesis factor 19	eukaryotic translation initiation factor 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Eukaryotic 43S Preinitiation Complex
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Translation Translational Initiation Regulation Of Translational Initiation Regulation Of Gene Expression Regulation Of Primary Metabolic Process
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	7 interacting genes: ATXN1 DVL2 DVL3 GRSF1 PEX19 SPG21 TRIM38
Entrez ID		5824	10289
HPRD ID		02610	17032
Ensembl ID		ENSG00000162735	ENSG00000114784
Uniprot IDs		A0A0S2Z497 P40855	O60739 Q6FG85
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Non-canonical Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Peroxisome Membrane Targeting Sequence Binding Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Mitochondrial RNA Catabolic Process Peroxisome Membrane Biogenesis Regulation Of JNK Cascade POZ Domain Binding Cytoplasm Convergent Extension Involved In Organogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Convergent Extension Involved In Gastrulation Protein Import Into Peroxisome Membrane Locomotory Behavior Mitochondrial RNA Catabolic Process Membrane Biogenesis Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding Poly(G) Binding Wnt Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Morphogenesis Regionalization Cytosol Protein Stabilization Protein Targeting To Peroxisome Protein Carrier Chaperone Peroxisome Fission Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway CD4 Receptor Binding Convergent Extension Small GTPase Binding Ribonucleoprotein Granule Positive Regulation Of Viral Entry Into Host Cell Regulation Of Nucleobase-containing Compound Metabolic Process Segment Specification Negative Regulation Of Defense Response To Virus
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