STK3 and SAV1

Number of citations of the paper that reports this interaction (PubMedID 15688006)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		STK3	SAV1
Description		serine/threonine kinase 3	salvador family WW domain containing protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity	Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Transcription Regulator Activator Activity
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Hair Follicle Development Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Keratinocyte Differentiation Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Keratinocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Stem Cell Population Maintenance
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs		Fostamatinib
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A	4 interacting genes: EP300 NEDD4 STK3 STK4
Entrez ID		6788	60485
HPRD ID		05433	06229
Ensembl ID		ENSG00000104375	ENSG00000151748
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	B3KTQ1 Q9H4B6
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66	6AO5
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity	Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Canonical Wnt Signaling Pathway Neural Tube Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Organelle Hepatocyte Apoptotic Process Hemopoiesis Positive Regulation Of Hippo Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Embryonic Epithelial Tube Formation Hippo Signaling Protein Stabilization Wnt Signaling Pathway Epithelial Tube Formation Negative Regulation Of Organ Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Regulation Of Hippo Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Epithelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organ Growth Positive Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Protein Stability Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Fat Cell Differentiation Protein Serine/threonine Kinase Activator Activity Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Protein Transport Formation Of Structure Involved In A Symbiotic Process Protein Tetramerization Positive Regulation Of Hepatocyte Apoptotic Process
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