STK3 and SLMAP

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology)

		STK3	SLMAP
Description		serine/threonine kinase 3	sarcolemma associated protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Centrosome Cytoskeleton Plasma Membrane Membrane Z Disc M Band Mitochondrial Membrane Sarcolemma FAR/SIN/STRIPAK Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Muscle Contraction Hippo Signaling Negative Regulation Of Hippo Signaling Protein Localization To Plasma Membrane Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Signaling by Hippo
Drugs		Fostamatinib
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 30578418) FEV1 ( 30804560) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Peak expiratory flow ( 30804560)
Interacting Genes		41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A	1 interacting genes: STK3
Entrez ID		6788	7871
HPRD ID		05433	04079
Ensembl ID		ENSG00000104375	ENSG00000163681
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	A0A590UJK3 A0A590UJS6 A0A5F9VB99 A0A994J5K5 B7Z6C7 B7Z863 B7Z964 H7C3M8 H7C5G9 Q14BN4
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66	6AKM 6AR0 6AR2
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity	Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity Glycine Catabolic Process Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Serine Family Amino Acid Catabolic Process Transcription Regulator Activator Activity Centrosome Separation Neural Tube Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Glycine Metabolic Process Transaminase Activity Hepatocyte Apoptotic Process Embryonic Epithelial Tube Formation Hippo Signaling Embryonic Hemopoiesis Positive Regulation Of Hippo Signaling Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Serine Family Amino Acid Metabolic Process Epithelial Tube Formation Negative Regulation Of Organ Growth Regulation Of Hippo Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Epithelial Cell Apoptotic Process Organ Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway JNK Cascade Positive Regulation Of Fat Cell Differentiation Protein Serine/threonine Kinase Activator Activity
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