STK3 and SLMAP

Number of citations of the paper that reports this interaction (PMID 24255178)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology)

		STK3	SLMAP
Gene Name		serine/threonine kinase 3	sarcolemma associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Smooth Endoplasmic Reticulum Microtubule Organizing Center Integral Component Of Plasma Membrane Sarcolemma
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity	Protein Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Muscle Contraction
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A	1 interactors: STK3
Entrez ID		6788	7871
HPRD ID		05433	04079
Ensembl ID		ENSG00000104375	ENSG00000163681
Uniprot IDs		B3KYA7 Q13188	Q14BN4
PDB IDs		4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death	Primitive Hemopoiesis Regulation Of Axon Regeneration Endocardium Development Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hippo Signaling Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Organ Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Fat Cell Differentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Protein Binding Execution Phase Of Apoptosis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Developmental Growth Protein Stabilization Regulation Of Organ Growth Embryonic Placenta Development Positive Regulation Of Binding Positive Regulation Of JNK Cascade Regulation Of Protein Kinase B Signaling Response To Hydrogen Peroxide Regulation Of Fat Cell Differentiation Neural Tube Formation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Stability Regulation Of Protein Binding Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of JNK Cascade Tube Formation Morphogenesis Of Embryonic Epithelium Regulation Of Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway Placenta Development Negative Regulation Of Wnt Signaling Pathway Response To Reactive Oxygen Species Neural Tube Development Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autophosphorylation Negative Regulation Of Cell Motility
Tagcloud ?		contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?		contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?