PEX19 and GSKIP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PEX19	GSKIP
Description		peroxisomal biogenesis factor 19	GSK3B interacting protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Kinase Regulator Activity Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Conotruncal heart defects (inherited effects) ( 28468790)
Interacting Genes		39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2	2 interacting genes: EXT2 PEX19
Entrez ID		5824	51527
HPRD ID		02610	16601
Ensembl ID		ENSG00000162735	ENSG00000100744
Uniprot IDs		A0A0S2Z497 P40855	Q9P0R6
PDB IDs		2W85 2WL8 3AJB 3MK4 5LNF	1SGO
Enriched GO Terms of Interacting Partners?		Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity UDP-N-acetylglucosamine Transferase Complex Heparan Sulfate N-acetylglucosaminyltransferase Activity Negative Regulation Of Lipid Binding Peroxisome Membrane Biogenesis Peroxisome Membrane Class-1 Targeting Sequence Binding Peroxisome Membrane Targeting Sequence Binding Heparin Proteoglycan Biosynthetic Process Endochondral Bone Morphogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Negative Regulation Of Ruffle Assembly Protein Targeting To Peroxisome Protein Carrier Chaperone Profilin Binding Peroxisome Fission Heparin Proteoglycan Metabolic Process Heparan Sulfate Proteoglycan Biosynthetic Process Acetylglucosaminyltransferase Activity Sulfation Catalytic Complex Heart Contraction Glycosaminoglycan Biosynthetic Process Animal Organ Morphogenesis Regulation Of Biological Quality Glucuronosyltransferase Activity Polysaccharide Biosynthetic Process Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Negative Regulation Of Epithelial Cell Migration Peroxisome Organization Multicellular Organismal-level Water Homeostasis Heparan Sulfate Proteoglycan Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ruffle Assembly Heart Process Bone Morphogenesis Fluid Transport Sodium Ion Homeostasis Response To Fibroblast Growth Factor Mesoderm Formation Glycosaminoglycan Metabolic Process Positive Regulation Of Actin Filament Polymerization Vasodilation Brush Border Membrane Positive Regulation Of Stress Fiber Assembly Chondrocyte Differentiation Formation Of Primary Germ Layer Proteoglycan Biosynthetic Process
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