PTPRS and PFN2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTPRS	PFN2
Description		protein tyrosine phosphatase receptor type S	profilin 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Alendronic acid Etidronic acid	Triglyme Pentaglyme
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Fish- and plant-related diet ( 32066663)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		5802	5217
HPRD ID		03344	01451
Ensembl ID		ENSG00000105426	ENSG00000070087
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	P35080
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	1D1J
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
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