PFN2 and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PFN2	FLT3LG
Description		profilin 2	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Signal Transduction Positive Regulation Of Cell Population Proliferation B Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis Dendritic Cell Differentiation
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	5 interacting genes: FLT3 KITLG KRTAP5-9 PFN2 S100A6
Entrez ID		5217	2323
HPRD ID		01451	02477
Ensembl ID		ENSG00000070087	ENSG00000090554
Uniprot IDs		P35080	B7ZLY4 P49771
PDB IDs		1D1J	1ETE 3QS7 3QS9 7NBI 7QDP 7ZV9
Enriched GO Terms of Interacting Partners?		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Positive Regulation Of Cell Population Proliferation Lymphocyte Proliferation Leukocyte Proliferation Hematopoietic Progenitor Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Mononuclear Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity Hemopoiesis Positive Regulation Of Protein Phosphorylation Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Mast Cell Migration Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Lymphoid Progenitor Cell Differentiation Positive Regulation Of Phosphate Metabolic Process Modification Of Postsynaptic Actin Cytoskeleton Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Pigmentation Tropomyosin Binding Nuclear Glucocorticoid Receptor Binding S100 Protein Binding Leukocyte Differentiation Positive Regulation Of Protein Modification Process Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Protein Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Phosphorylation Modification Of Postsynaptic Structure
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?