PFN2 and NDUFB8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	NDUFB8
Gene Name		profilin 2	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Endoplasmic Reticulum Integral Component Of Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Axon guidance Signaling by Robo receptor	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS			Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	6 interactors: ATP6V0D2 CACNA1A EIF2B3 PFN2 PIM2 ZAP70
Entrez ID		5217	4714
HPRD ID		01451	11886
Ensembl ID		ENSG00000070087	ENSG00000166136
Uniprot IDs		G5E9Q6 P35080	O95169
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly	Regulation Of Neurotransmitter Secretion Cerebellar Molecular Layer Development Vestibular Nucleus Development Beta Selection Regulation Of Exocytosis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Protein Autophosphorylation Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Negative Regulation Of Ruffle Assembly Negative Regulation Of Translational Initiation In Response To Stress Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Negative Regulation Of Translation In Response To Stress Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Synaptic Transmission Positive Thymic T Cell Selection Negative Regulation Of Hormone Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Pons Development Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Cerebellar Purkinje Cell Differentiation Negative T Cell Selection Regulation Of Translation In Response To Stress Cellular Metal Ion Homeostasis Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Ruffle Assembly T Cell Migration Negative Regulation Of Translational Initiation Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Reflex Metal Ion Homeostasis Behavioral Response To Pain Thymic T Cell Selection Regulation Of Cell Projection Organization Response To Peptide Neuromuscular Synaptic Transmission
Tagcloud ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?