PTPRS and PPFIA3

Number of citations: 0 (PubMedID 9624153)
Data Source: HPRD (in vitro)

		PTPRS	PPFIA3
Name		protein tyrosine phosphatase receptor type S	PPFI scaffold protein A3
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Acrosomal Vesicle Cytoplasm Cytosol Cytoplasmic Vesicle Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Epididymosome Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	Neurotransmitter Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs		Alendronic acid Etidronic acid	None
GWAS		Thyroid stimulating hormone levels ( 32769997 ) Type 2 diabetes ( 30297969 ) Waist-hip ratio ( 28552196 )	Adult body size ( 32376654 ) Leukoderma in response to rhododendrol ( 32558222 )
Novel Interactors		None recorded	1 novel interactors: ATP1A3
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	17 interacting genes: CAST CBY2 CNKSR1 DISC1 ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PPP1R13B PTPRD PTPRF PTPRS PTPRU SORBS3 TFIP11
Entrez ID		5802	8541
HPRD ID		03344	04393
Ensembl ID		ENSG00000105426	ENSG00000177380
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	O75145
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	Not available
GO Terms Enriched among Interactors		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	Presynaptic Active Zone Synapse Organization Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Dendritic Spine Development Cell Junction Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Adhesion Synaptic Membrane Adhesion Protein Tyrosine Phosphatase Activity Maintenance Of Synapse Structure Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Postsynapse Organization Glutamatergic Synapse Cell Junction Maintenance Cortical Microtubule Organization Axon Presynaptic Active Zone Organization Cellular Component Maintenance Maintenance Of Postsynaptic Specialization Structure Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Presynapse Protein Dephosphorylation Regulation Of Postsynaptic Density Assembly Modulation Of Chemical Synaptic Transmission Postsynaptic Density Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Presynapse Organization Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Synapse Postsynaptic Specialization Organization Dephosphorylation Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cell-substrate Adhesion Neuromuscular Junction Development Regulation Of Response To Wounding Cell Cortex Focal Adhesion Regulation Of Dendritic Spine Morphogenesis