PFN2 and FHOD1

Number of citations of the paper that reports this interaction (PMID 12677009)
9

Data Source:
HPRD (two hybrid, in vitro)

		PFN2	FHOD1
Gene Name		profilin 2	formin homology 2 domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome	Stress Fiber Nucleus Cytoplasm Membrane Bleb
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stress Fiber Assembly
Pathways		Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	20 interactors: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 YWHAZ ZMYND8
Entrez ID		5217	29109
HPRD ID		01451	06049
Ensembl ID		ENSG00000070087	ENSG00000135723
Uniprot IDs		G5E9Q6 P35080	Q9Y613
PDB IDs		1D1J	3DAD
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly	Nonmotile Primary Cilium Assembly Cell Projection Organization Retina Homeostasis Cell Projection Morphogenesis Cell Part Morphogenesis Tissue Homeostasis Positive Regulation Of Organelle Organization Cellular Component Assembly Cell Morphogenesis Organelle Organization Multicellular Organismal Homeostasis Organelle Assembly Cytoskeleton Organization Cellular Response To Stimulus Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Photoreceptor Cell Maintenance Cell Differentiation Cell Projection Assembly Fat Cell Differentiation Melanosome Transport Pigment Granule Transport Membrane Organization Establishment Of Melanosome Localization Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Nervous System Development Regulation Of Organelle Organization Melanosome Localization Signal Transduction Cell Development Organ Development Homeostatic Process Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Cilium Assembly Visual Perception Sensory Perception Of Light Stimulus Anatomical Structure Formation Involved In Morphogenesis Cell Activation Signaling Cilium Organization Leptin-mediated Signaling Pathway Cell Communication Cellular Pigmentation Platelet Activation Anatomical Structure Development Blood Coagulation
Tagcloud ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrin integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy hcls1 integration itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	actin adhesions adhesive arrays assembly bilayers clusters coordinated depends find force formin impairs insights integrins matrix maturation pillar polymerization question raises recruited rho sensing spreading steps substrates upstream
Tagcloud (Intersection) ?		integrin