PFN2 and IK

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	IK
Description		profilin 2	IK cytokine
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytoplasm Cytoskeleton Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome MRNA Processing Mitotic Spindle Assembly Checkpoint Signaling RNA Splicing Protein Localization To Kinetochore
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	mRNA Splicing - Major Pathway
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Monocyte count ( 32888494) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	28 interacting genes: APP CEBPA CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10
Entrez ID		5217	3550
HPRD ID		01451	02771
Ensembl ID		ENSG00000070087	ENSG00000113141
Uniprot IDs		P35080	Q13123 Q95HA6 Q9UK43
PDB IDs		1D1J	5O9Z 6Q8I 8QO9 8QZS
Enriched GO Terms of Interacting Partners?		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus PTB Domain Binding Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Death Regulation Of Programmed Cell Death RNA Binding Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Regulation Of Apoptotic Process Carbohydrate Homeostasis Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Glucose Homeostasis Regulation Of Stem Cell Differentiation NuRD Complex Negative Regulation Of Translation Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing Cellular Response To Carbohydrate Stimulus Positive Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Translation Regulator Activity Intracellular Glucose Homeostasis
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