PFN2 and IVNS1ABP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	IVNS1ABP
Gene Name		profilin 2	influenza virus NS1A binding protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome	Nucleoplasm Transcription Factor Complex Spliceosomal Complex Cytoplasm Actin Cytoskeleton
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Transcription From RNA Polymerase III Promoter RNA Splicing Response To Virus Viral Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	8 interactors: AHR CHD3 PFN2 RPL6 SYNCRIP TRA2B VIM ZNRD1
Entrez ID		5217	10625
HPRD ID		01451	10004
Ensembl ID		ENSG00000070087	ENSG00000116679
Uniprot IDs		G5E9Q6 P35080	A8MVR0 Q9Y6Y0
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly	Regulation Of Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Gene Expression MRNA Metabolic Process Viral Process Negative Regulation Of Cell Projection Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly CRD-mediated MRNA Stabilization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Ruffle Assembly Bergmann Glial Cell Differentiation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cytoskeleton Organization Regulation Of Protein Complex Assembly RNA Biosynthetic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter RNA Splicing Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of Ruffle Assembly Intermediate Filament Organization Lens Fiber Cell Development
Tagcloud ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	11q 13q 14q 15q 1q 21q 22q 2q 3q 4p 4q 9q acgh acsl1 atp8b4 bcl1 fbxl5 imbalances irf2bp2 jh lamp2 myeloma nampt picalm q13 q32 samsn1 stk17b xq
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	11q 13q 14q 15q 1q 21q 22q 2q 3q 4p 4q 9q acgh acsl1 atp8b4 bcl1 fbxl5 imbalances irf2bp2 jh lamp2 myeloma nampt picalm q13 q32 samsn1 stk17b xq
Tagcloud (Intersection) ?