PTPRS and OMG

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		PTPRS	OMG
Description		protein tyrosine phosphatase receptor type S	oligodendrocyte myelin glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	Cell Adhesion Neuron Projection Regeneration
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Axonal growth inhibition (RHOA activation)
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Brain morphology (MOSTest) ( 32665545) Diverticular disease ( 30177863) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	6 interacting genes: PTPRD PTPRF PTPRS PTPRU RTN4R RTN4RL1
Entrez ID		5802	4974
HPRD ID		03344	01257
Ensembl ID		ENSG00000105426	ENSG00000126861
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	P23515
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	Regulation Of Neuron Projection Regeneration Regulation Of Axon Regeneration Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Chondroitin Sulfate Binding Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Tyrosine Phosphatase Activity Corpus Callosum Development Synaptic Membrane Adhesion Phosphoprotein Phosphatase Activity Regulation Of Neuron Projection Development Heparin Binding Regulation Of Synapse Assembly Regulation Of Response To Wounding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cell Projection Organization Regulation Of Synapse Organization Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regeneration Dephosphorylation Regulation Of Postsynaptic Density Assembly Regulation Of Postsynapse Organization Perikaryon Cell-cell Adhesion Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Response To Stress Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Projection Organization Neuron Projection Regeneration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Negative Regulation Of Axon Extension Developmental Process Cell Adhesion Regulation Of Dendritic Spine Development Negative Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Neuron Projection Regulation Of Neurogenesis Chondroitin Sulfate Proteoglycan Binding Extracellular Exosome Regulation Of Axon Extension Cell Projection Organization Cell Adhesion Molecule Binding Negative Regulation Of Developmental Growth Schaffer Collateral - CA1 Synapse
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