PTPRS

Description		protein tyrosine phosphatase receptor type S
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A
Entrez ID		5802
HPRD ID		03344
Ensembl ID		ENSG00000105426
Uniprot IDs		Q13332 Q59FX6 Q8NHS7
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity
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