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PFN2 and DNM1
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(biochemical)
HPRD
(in vitro, in vivo)
PFN2
DNM1
Description
profilin 2
dynamin 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Cytoplasm
Microtubule
Plasma Membrane
Clathrin-coated Pit
Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Chromaffin Granule
Cell Projection
Synapse
Extracellular Exosome
Presynapse
Molecular Function
Actin Binding
Actin Monomer Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
ATP Hydrolysis Activity
Nucleotide Binding
RNA Binding
GTPase Activity
Protein Binding
GTP Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Microtubule Binding
Hydrolase Activity
GDP Binding
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Epithelial Cell Migration
Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Actin Filament Bundle Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Positive Regulation Of Stress Fiber Assembly
Modification Of Postsynaptic Actin Cytoskeleton
Presynaptic Actin Cytoskeleton Organization
Presynaptic Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Ruffle Assembly
Regulation Of Synaptic Vesicle Exocytosis
Endocytosis
Receptor-mediated Endocytosis
Endosome Organization
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Protein Homooligomerization
Protein Homotetramerization
Regulation Of Vesicle Size
Clathrin Coat Assembly Involved In Endocytosis
Vesicle Scission
Pathways
Signaling by ROBO receptors
RHO GTPases Activate Formins
RHO GTPases Activate Formins
Toll Like Receptor 4 (TLR4) Cascade
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Clathrin-mediated endocytosis
Drugs
Triglyme
Pentaglyme
Diseases
GWAS
Fish- and plant-related diet (
32066663
)
Attention deficit hyperactivity disorder (
18839057
)
Body mass index (
26426971
)
Coenzyme Q10 levels (
27149984
)
Platelet distribution width (
32888494
)
Interacting Genes
34 interacting genes:
ACTB
ACTG1
ANTKMT
BIRC2
CFAP263
DDX11
DLST
DNM1
EEF1A1
ERCC6
EVL
FHOD1
FLT3LG
FMNL1
GOLGB1
HTT
IK
IVNS1ABP
MSANTD3
MYPOP
NDUFB8
PLAUR
PTPRS
RAP1GAP
RNF146
ROCK1
RPS10
SEPTIN5
SGTA
SNTA1
SYN1
TERF1
VASP
WDR33
53 interacting genes:
AMPH
AP2A2
ASB13
BIN1
CABIN1
CAV1
CDK5
CEP126
CLIC3
CLIC4
CLINT1
CTTN
DNMBP
DYRK1A
EPS15
FILNC1
FNBP1
FTCD
GRB2
GRIN1
GRIN2D
HSPA13
ITSN1
MAP3K10
MED31
MOB4
NCK1
NCK2
NME2
PACSIN1
PACSIN2
PACSIN3
PCNT
PFN2
PIAS1
PIK3R1
PIN4
PLCG1
PLK2
PRKCA
PRNP
RACK1
RNF10
SH3GL1
SH3GL2
SH3GL3
SNAP25
SNCA
SNX9
SRC
SUMO1
TIMM50
UBE2I
Entrez ID
5217
1759
HPRD ID
01451
03851
Ensembl ID
ENSG00000070087
ENSG00000106976
Uniprot IDs
P35080
A0A994J7J4
B4DK06
B7ZAC0
Q05193
PDB IDs
1D1J
1DYN
2DYN
2X2E
2X2F
3SNH
3ZYC
3ZYS
4UUD
4UUK
5D3Q
6DLU
6DLV
6S9A
7AX3
8SXZ
8SZ4
8SZ7
8SZ8
8T0K
8T0R
8TYM
8TYN
Enriched GO Terms of Interacting Partners
?
Profilin Binding
Cytoskeleton
Bleb
Schaffer Collateral - CA1 Synapse
Regulation Of Organelle Organization
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Transepithelial Transport
Regulation Of Synaptic Vesicle Recycling
Dense Body
Regulation Of Stress Fiber Assembly
Morphogenesis Of A Polarized Epithelium
Response To Bleomycin
Positive Regulation Of Organelle Organization
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Identical Protein Binding
Actin Binding
Cell Projection
Axon
Regulation Of Cellular Component Organization
Focal Adhesion
Regulation Of Actin Filament Organization
Nitric-oxide Synthase Binding
Protein Homotetramerization
Positive Regulation Of Cellular Component Organization
Negative Regulation Of Cellular Component Organization
Postsynaptic Actin Cytoskeleton Organization
Positive Regulation Of Cellular Component Biogenesis
Lamellipodium
Regulation Of Actin Cytoskeleton Organization
Protein Localization To Cell-cell Junction
Calyx Of Held
Actin Cytoskeleton Organization
Regulation Of Vesicle-mediated Transport
Postsynaptic Cytoskeleton Organization
Protein Tetramerization
Regulation Of Actin Filament-based Process
Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Double-strand Break Repair
Apical Junction Complex
Actin Filament-based Process
Protein Kinase Binding
NuA4 Histone Acetyltransferase Complex
Maintenance Of Blood-brain Barrier
Regulation Of Chromosome Organization
Positive Regulation Of Norepinephrine Uptake
Cellular Response To Cytochalasin B
Basal Body Patch
Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process
Cortical Actin Cytoskeleton Organization
Negative Regulation Of Protein Binding
Endocytosis
Import Into Cell
Synaptic Vesicle Endocytosis
Vesicle-mediated Transport In Synapse
Presynaptic Endocytosis
Glutamatergic Synapse
Cytoplasm
Lipid Binding
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Transport
Regulation Of Vesicle-mediated Transport
Vesicle-mediated Transport
Positive Regulation Of Actin Filament Polymerization
Regulation Of Endocytosis
Positive Regulation Of Cellular Component Biogenesis
Cytosol
Regulation Of Biological Quality
Regulation Of Cellular Component Organization
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Polymerization
Perinuclear Region Of Cytoplasm
Presynapse
Cellular Component Assembly
Receptor-mediated Endocytosis
Negative Regulation Of Endocytosis
Plasma Membrane
Plasma Membrane Tubulation
Clathrin-coated Pit
Phospholipid Binding
Regulation Of Actin Filament Polymerization
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Regulation Of Synaptic Plasticity
Cytoskeleton
Regulation Of Actin Filament-based Process
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Polymerization Or Depolymerization
Modulation Of Chemical Synaptic Transmission
Regulation Of Actin Filament Length
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Protein Metabolic Process
Regulation Of Calcium Ion Transport
Cadherin Binding
Neurotrophin TRKA Receptor Binding
Regulation Of Cytoskeleton Organization
Synapse
Negative Regulation Of Transport
Long-term Synaptic Potentiation
Regulation Of Signaling
Regulation Of Apoptotic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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