PFN2 and MYPOP

Number of citations of the paper that reports this interaction (PMID 15615774)
8

Data Source:
HPRD (two hybrid, in vivo)

		PFN2	MYPOP
Gene Name		profilin 2	Myb-related transcription factor, partner of profilin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	2 interactors: PFN1 PFN2
Entrez ID		5217	339344
HPRD ID		01451	17352
Ensembl ID		ENSG00000070087	ENSG00000176182
Uniprot IDs		G5E9Q6 P35080	Q86VE0
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly	Regulation Of Ruffle Assembly Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Negative Regulation Of Protein Complex Assembly Regulation Of Epithelial Cell Migration Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Organelle Organization Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Ruffle Assembly Regulation Of Cell Migration Actin Cytoskeleton Organization Regulation Of Cell Motility Actin Filament-based Process Regulation Of Locomotion Regulation Of Cellular Component Movement Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Positive Regulation Of Hydrolase Activity Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Positive Regulation Of Viral Transcription Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Neurotransmitter Secretion Regulation Of Viral Transcription Platelet Degranulation Positive Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation
Tagcloud ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?