PTPRS and SLITRK1

Number of citations of the paper that reports this interaction (PubMedID 25394468)
0

Data Source:
BioGRID (pull down)

		PTPRS	SLITRK1
Description		protein tyrosine phosphatase receptor type S	SLIT and NTRK like family member 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Plasma Membrane Membrane Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	Endocytosis Nervous System Development Axonogenesis Synapse Assembly Gene Expression Adult Behavior Multicellular Organism Growth Norepinephrine Metabolic Process Homeostatic Process Positive Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Vocalization Behavior Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Neuron Projection Extension
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Receptor-type tyrosine-protein phosphatases
Drugs		Alendronic acid Etidronic acid
Diseases			Tourette syndrome Trichotillomania
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder (mania) ( 23326512) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid deposition (PET imaging) ( 30361487) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Hepcidin/transferrin saturation ratio ( 27846281) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Squamous cell lung carcinoma ( 28604730) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	3 interacting genes: PTPRD PTPRS UBQLN2
Entrez ID		5802	114798
HPRD ID		03344	18063
Ensembl ID		ENSG00000105426	ENSG00000178235
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	Q96PX8
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	4RCA 4RCW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	Regulation Of Postsynaptic Specialization Assembly Regulation Of Postsynaptic Density Assembly Regulation Of Organelle Assembly Regulation Of Excitatory Synapse Assembly Synaptic Membrane Adhesion Regulation Of Dendritic Spine Development Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Regulation Of Postsynapse Organization Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Synapse Assembly Regulation Of Organelle Organization Negative Regulation Of G Protein-coupled Receptor Internalization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cell Junction Assembly Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Interferon-alpha Production Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Synapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Trans-synaptic Signaling Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Synaptic Signaling Regulation Of Neurogenesis Presynaptic Membrane Assembly Negative Regulation Of Dendritic Spine Development Presynaptic Membrane Organization Chondroitin Sulfate Binding Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Presynapse Assembly Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Interferon-beta Production Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Presynapse Organization Glutamatergic Synapse Positive Regulation Of Dendritic Spine Morphogenesis Corpus Callosum Development Regulation Of Cellular Response To Stress Heparan Sulfate Proteoglycan Binding Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization
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