PTPRS and GPC3

Number of citations of the paper that reports this interaction (PubMedID 25624497)
43

Data Source:
BioGRID (pull down)

		PTPRS	GPC3
Description		protein tyrosine phosphatase receptor type S	glypican 3
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Lysosome Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Side Of Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Binding Peptidase Inhibitor Activity Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Smoothened Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Bacterium Anatomical Structure Morphogenesis Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Signal Transduction Body Morphogenesis Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Regulation Of Growth Cell Migration Involved In Gastrulation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of D-glucose Import Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs		Alendronic acid Etidronic acid
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	6 interacting genes: APPL1 FGF2 IGF2 PTPRS WNT3A WNT7B
Entrez ID		5802	2719
HPRD ID		03344	02074
Ensembl ID		ENSG00000105426	ENSG00000147257
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	7ZA1 7ZAW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	Positive Regulation Of Cell Fate Specification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Embryonic Placenta Morphogenesis Regulation Of Developmental Growth Canonical Wnt Signaling Pathway Embryonic Morphogenesis Osteoblast Differentiation Positive Regulation Of Cell Fate Commitment Receptor Ligand Activity Regulation Of Growth Positive Regulation Of Developmental Growth Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Collateral Sprouting Regulation Of Cell Fate Specification Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Regulation Of Skeletal Muscle Tissue Development Regulation Of Cell Differentiation Cytokine Activity Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Growth Chordate Embryonic Development In Utero Embryonic Development Synapse Organization Frizzled Binding Regulation Of Cell Communication Regulation Of Signaling Wnt Signaling Pathway Regulation Of Fibroblast Migration Regulation Of Striated Muscle Tissue Development Cell Development Positive Chemotaxis Regulation Of Muscle Organ Development Regulation Of Cell Fate Commitment Cell Surface Receptor Signaling Pathway Positive Regulation Of Organ Growth Non-canonical Wnt Signaling Pathway Negative Regulation Of Axonogenesis Positive Regulation Of Neural Precursor Cell Proliferation Neuron Differentiation Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Retinoic Acid Signal Transduction Tissue Morphogenesis Hippocampus Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?