PFN2 and CFAP263

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	CFAP263
Description		profilin 2	cilia and flagella associated protein 263
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytoskeleton Cilium Axoneme Protein-containing Complex Centriolar Satellite Ciliary Basal Body Cell Projection
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Protein Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Cell Projection Organization Cilium Assembly
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	6 interacting genes: GIT1 HAP1 HSF2BP IMMT PFN2 SMYD1
Entrez ID		5217	29070
HPRD ID		01451	07121
Ensembl ID		ENSG00000070087	ENSG00000103021
Uniprot IDs		P35080	Q9H0I3
PDB IDs		1D1J	8J07
Enriched GO Terms of Interacting Partners?		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Regulation Of Exocytosis Presynapse Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Protein Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Neurotransmitter Secretion Regulation Of Secretion By Cell Positive Regulation Of Organelle Organization Regulation Of Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neurotrophin Production Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of ARF Protein Signal Transduction Structural Constituent Of Postsynaptic Specialization Regulation Of Secretion Regulation Of Regulated Secretory Pathway Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Growth Cone Positive Regulation Of Supramolecular Fiber Organization Presynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytoskeleton Organization Hypothalamus Cell Differentiation Mitochondrial Crista Junction Intramembranous Ossification Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly MICOS Complex Female Meiosis I Motor Learning Regulation Of Cell Projection Assembly Postsynapse Brain Development Synapse Organization Regulation Of Microtubule-based Process Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly SAM Complex MIB Complex Double-strand Break Repair Involved In Meiotic Recombination Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Negative Regulation Of Inflammatory Response To Wounding Histone H3K4 Trimethyltransferase Activity Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Non-motile Cilium Assembly Cristae Formation
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