PFN2 and MSANTD3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PFN2	MSANTD3
Description		profilin 2	Myb/SANT DNA binding domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Protein Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Conjunctival UV autofluorescence (CUVAF) ( 25590795)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	16 interacting genes: BMPR1A BUB1 CDH1 FXR1 FXR2 GNAS MCC MLH3 MUTYH PFN2 SMAD4 SUV39H1 TMEM129 TSC1 VSTM2A ZDHHC17
Entrez ID		5217	91283
HPRD ID		01451	14459
Ensembl ID		ENSG00000070087	ENSG00000066697
Uniprot IDs		P35080	Q96H12
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Cellular Response To BMP Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Mesendoderm Development Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Multicellular Organismal Process Postsynapse Modulation Of Chemical Synaptic Transmission Cardiac Conduction System Development Negative Regulation Of Epithelial Cell Migration Translation Regulator Activity Animal Organ Development Regulation Of Growth Regulation Of Developmental Growth Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Locomotion Outflow Tract Septum Morphogenesis Regulation Of Neurogenesis Mismatch Repair Positive Regulation Of Cellular Component Organization Pituitary Gland Development Endoderm Development Regulation Of Multicellular Organismal Process Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Cellular Senescence Ventricular Septum Morphogenesis Regulation Of Cell Development Regulation Of Developmental Process SMAD Binding Ventricular Cardiac Muscle Tissue Morphogenesis Neural Plate Mediolateral Regionalization Paraxial Mesoderm Structural Organization Positive Regulation Of Cell Differentiation Fibrous Ring Of Heart Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Lamellipodium Cardiocyte Differentiation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
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