PTPRS and GPC2

Number of citations of the paper that reports this interaction (PubMedID 25624497)
43

Data Source:
BioGRID (pull down)

		PTPRS	GPC2
Description		protein tyrosine phosphatase receptor type S	glypican 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Synapse Side Of Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	Smoothened Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Neuron Differentiation Regulation Of Protein Localization To Membrane
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	1 interacting genes: PTPRS
Entrez ID		5802	221914
HPRD ID		03344	17051
Ensembl ID		ENSG00000105426	ENSG00000213420
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	Q8N158
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	6WJL 7T62
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	Regulation Of Collateral Sprouting Corpus Callosum Development Regulation Of Toll-like Receptor 9 Signaling Pathway Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Interferon-beta Production Negative Regulation Of Collateral Sprouting Regulation Of Postsynaptic Specialization Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Postsynaptic Density Assembly Negative Regulation Of Axon Regeneration Negative Regulation Of Interferon-alpha Production Heparan Sulfate Proteoglycan Binding Chondroitin Sulfate Binding Negative Regulation Of Neuron Projection Regeneration Regulation Of Excitatory Synapse Assembly Negative Regulation Of Dendritic Spine Development Synaptic Membrane Adhesion Spinal Cord Development Regulation Of Neuron Projection Regeneration Negative Regulation Of Axon Extension Regulation Of Axon Regeneration Establishment Of Endothelial Barrier Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Endothelial Cell Development Negative Regulation Of Type I Interferon Production Cerebellum Development Negative Regulation Of Axonogenesis Regulation Of Dendritic Spine Development Regulation Of Interferon-beta Production Hippocampus Development Cerebral Cortex Development Protein Dephosphorylation Regulation Of Axon Extension Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Negative Regulation Of Developmental Growth Postsynaptic Density Membrane Perikaryon Epithelial Cell Development Growth Cone Regulation Of Postsynapse Organization Negative Regulation Of Nervous System Development Regulation Of Type I Interferon Production Regulation Of Axonogenesis Dephosphorylation Presynaptic Membrane Synaptic Vesicle Membrane Negative Regulation Of Neurogenesis
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