PTPRS and UTP14A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTPRS	UTP14A
Description		protein tyrosine phosphatase receptor type S	UTP14A small subunit processome component
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Hydrolase Activity Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding	RNA Binding Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Synapse Organization Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Synaptic Membrane Adhesion	RRNA Processing Ribosome Biogenesis
Pathways		ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Alendronic acid Etidronic acid
Diseases
GWAS		Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)
Interacting Genes		28 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 OMG PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A	54 interacting genes: AKTIP APLP1 APP ARIH2 AXIN1 BICD2 CCDC106 CCDC85B CEP70 CPE CSNK2A1 CSNK2B DLEU1 EXOSC8 GADD45G HNRNPH3 HOOK1 HOOK2 HTT KRT31 LAMTOR5 LDOC1 LMO1 LSM3 NIN NINL PDCD5 PDZK1IP1 PHF10 PRKCZ PSG1 PTEN PTPRS RABIF RGS1 RHOH RNF10 RPA2 RSRC1 SAT1 SMYD1 SNRNP48 SSR1 TERF1 TFIP11 TINAGL1 TP53 TP53BP2 TRDMT1 TXLNB USO1 VIM WDR33 ZNF24
Entrez ID		5802	10813
HPRD ID		03344	06712
Ensembl ID		ENSG00000105426	ENSG00000156697
Uniprot IDs		Q13332 Q59FX6 Q8NHS7	Q9BVJ6
PDB IDs		2FH7 2YD2 2YD3 2YD9 4BPC 4PBX	7MQ8 7MQ9 7MQA 7WTS
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Tyrosine Phosphatase Activity Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Cellular Component Organization Cell Adhesion Side Of Membrane Synapse Organization Presynaptic Active Zone Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoprotein Phosphatase Activity Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Regulation Of Cellular Localization Glutamatergic Synapse Positive Regulation Of Cell Projection Organization Regulation Of Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cellular Component Organization Lysosomal Lumen Presynapse Organization Intercellular Bridge Positive Regulation Of Peptidyl-serine Phosphorylation Golgi Lumen Synapse Synaptic Membrane Adhesion Microtubule Cytoskeleton Organization Cell Junction Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Cellular Response To Estradiol Stimulus Multivesicular Body, Internal Vesicle Lumen Peptidyl-dipeptidase Inhibitor Activity Cell Projection Organization Structural Constituent Of Presynapse Epididymosome Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Histone H2AK5 Acetyltransferase Activity	FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Organization Microtubule Anchoring At Microtubule Organizing Center HOPS Complex MRNA Metabolic Process Identical Protein Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body PML Body Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Cellular Localization Organelle Organization Microtubule Anchoring Early Endosome To Late Endosome Transport P53 Binding Dynein Light Intermediate Chain Binding Apoptotic Process Positive Regulation Of Aggrephagy Central Nervous System Development Cytoplasm Programmed Cell Death Cell Death Positive Regulation Of Excitatory Postsynaptic Potential Fibrillar Center Microtubule-based Process Cytoskeleton Organization Microtubule Organizing Center Intracellular Transport Nucleus Cytoskeleton-dependent Intracellular Transport G-rich Strand Telomeric DNA Binding Cellular Response To Muramyl Dipeptide Modulation Of Excitatory Postsynaptic Potential Developmental Cell Growth Microtubule Anchoring At Centrosome Regulation Of Nervous System Process Endosome To Lysosome Transport Nuclear Matrix Supramolecular Fiber Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Centrosome Nucleoplasm Dynactin Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nervous System Development Cytoplasmic Microtubule Organization
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