PFN2 and DDX11

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PFN2	DDX11
Name		profilin 2	DEAD/H-box helicase 11
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse	Chromatin Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytoskeleton Midbody Mitotic Cohesin Complex Extracellular Exosome
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent Activity, Acting On RNA Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Modulation Of Chemical Synaptic Transmission Protein Stabilization Positive Regulation Of Stress Fiber Assembly Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Replication Fork Processing Negative Regulation Of Protein Binding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	XBP1(S) activates chaperone genes
Drugs		Triglyme Pentaglyme	None
Diseases		None	Warsaw breakage syndrome
GWAS		Fish- and plant-related diet ( 32066663 )	No GWAS studies recorded
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CFAP263 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	4 interacting genes: EIF4ENIF1 KAT7 PFN2 PRRC2B
Entrez ID		5217	1663
HPRD ID		01451	03095
Ensembl ID		ENSG00000070087	ENSG00000013573
Uniprot IDs		P35080	Q2NKM7 Q96FC9
PDB IDs		1D1J	Not available
GO Terms Enriched among Interactors		Profilin Binding Cytoskeleton Bleb Schaffer Collateral - CA1 Synapse Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Recycling Dense Body Regulation Of Stress Fiber Assembly Morphogenesis Of A Polarized Epithelium Response To Bleomycin Positive Regulation Of Organelle Organization Structural Constituent Of Postsynaptic Actin Cytoskeleton Identical Protein Binding Actin Binding Cell Projection Axon Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Actin Filament Organization Nitric-oxide Synthase Binding Protein Homotetramerization Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Actin Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Postsynaptic Cytoskeleton Organization Protein Tetramerization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Double-strand Break Repair Apical Junction Complex Actin Filament-based Process Protein Kinase Binding NuA4 Histone Acetyltransferase Complex Maintenance Of Blood-brain Barrier Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Cortical Actin Cytoskeleton Organization Negative Regulation Of Protein Binding	Maintenance Of Protein Localization At Cell Tip Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Histone H3-K14 Acetyltransferase Complex Response To Dithiothreitol Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Alpha-catenin Binding Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Desmosome Assembly Internal Protein Amino Acid Acetylation Response To Anisomycin Internal Peptidyl-lysine Acetylation DNA Replication-dependent Chromatin Disassembly Response To Hydroxyurea Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Response To Sorbitol Histone H3 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Response To Actinomycin D Positive Regulation Of Hematopoietic Stem Cell Proliferation Histone H4 Acetyltransferase Activity Nuclear Export Signal Receptor Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Peptidyl-lysine Acetylation Negative Regulation Of Epithelial Cell Migration Regulation Of Actin Filament-based Process Desmosome Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding P-body Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Hematopoietic Stem Cell Proliferation Natural Killer Cell Differentiation Modification Of Postsynaptic Structure