PFN2 and DDX11

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	DDX11
Gene Name		profilin 2	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome	Nuclear Chromatin Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Midbody Extracellular Vesicular Exosome
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding	Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis	Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Sister Chromatid Cohesion Viral Process Endoplasmic Reticulum Unfolded Protein Response DNA Duplex Unwinding Cellular Protein Metabolic Process
Pathways		Axon guidance Signaling by Robo receptor	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	2 interactors: KAT7 PFN2
Entrez ID		5217	1663
HPRD ID		01451	03095
Ensembl ID		ENSG00000070087	ENSG00000013573
Uniprot IDs		G5E9Q6 P35080	Q2NKM7 Q96FC9
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly	Negative Regulation Of Ruffle Assembly Histone H4-K12 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Ruffle Assembly Positive Regulation Of ATPase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Regulation Of ATPase Activity Positive Regulation Of Stress Fiber Assembly Histone H3 Acetylation Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Bundle Assembly Histone H4 Acetylation Regulation Of Stress Fiber Assembly Regulation Of Neurotransmitter Secretion Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation
Tagcloud ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	acidophilum chlr1 cpu cyclopurine deoxynucleosides ding distorting dnab fancj helicase helicases impeded ner pigmentosum recq recq1 sf1 sf2 sf4 taxpd thermoplasma translocating unwind unwinding uvrd wrn xeroderma xp xpd
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set signature	acidophilum chlr1 cpu cyclopurine deoxynucleosides ding distorting dnab fancj helicase helicases impeded ner pigmentosum recq recq1 sf1 sf4 taxpd thermoplasma translocating unwind unwinding uvrd wrn xeroderma xp xpd
Tagcloud (Intersection) ?		sf2