AJUBA and ZNF541

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AJUBA	ZNF541
Description		ajuba LIM protein	zinc finger protein 541
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Membrane Lamellipodium Anchoring Junction	Histone Deacetylase Complex Nucleus Transcription Regulator Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Kinase Activator Activity Alpha-catenin Binding Metal Ion Binding Actin Filament Binding	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of DNA-templated Transcription Cytoskeleton Organization Cell Adhesion Intracellular Protein Localization Positive Regulation Of Biosynthetic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Protein-containing Complex Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Male Meiotic Nuclear Division Spermatogenesis Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of PLK1 Activity at G2/M Transition Activation of anterior HOX genes in hindbrain development during early embryogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Insular cortex volume ( 31530798) Macular thickness ( 30535121) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Spatial processing ( 31596458)	Bipolar disorder ( 31043756)
Interacting Genes		24 interacting genes: ACTA1 AURKA AURKAIP1 AURKB BCAR1 CATSPER1 CREB5 CTNNA1 FARS2 GFI1B GRB2 ITSN1 LATS2 LCK LGALS14 PIN1 RPA1 SLC1A2 TEKT3 TFAP4 TSG101 WEE2-AS1 ZNF512B ZNF541	2 interacting genes: AJUBA TRIP6
Entrez ID		84962	84215
HPRD ID		16426	10337
Ensembl ID		ENSG00000129474	ENSG00000118156
Uniprot IDs		Q96IF1	Q9H0D2
PDB IDs
Enriched GO Terms of Interacting Partners?		B Cell Receptor Signaling Pathway Chromosome Passenger Complex Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Lamellipodium Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Cytokinesis Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Meiotic Cell Cycle Spindle Midzone Negative Regulation Of Protein Phosphorylation Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Phosphorylation Protein Serine/threonine/tyrosine Kinase Activity Nucleus Regulation Of Protein Localization To Nucleus Guanyl-nucleotide Exchange Factor Adaptor Activity Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Nuclear Division Cis-trans Isomerase Activity Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Phase Transition Spindle Pole Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Brood Size Outer Acrosomal Membrane Spindle Microtubule Negative Regulation Of Phosphate Metabolic Process T Cell Costimulation Centrosome Regulation Of Cell Division Regulation Of Protein Phosphorylation	Cell-substrate Junction Organization Focal Adhesion Assembly Cell-substrate Junction Assembly Cell Junction Assembly Anchoring Junction Focal Adhesion Cell Junction Organization Alpha-catenin Binding Interleukin-1 Receptor Binding Wound Healing, Spreading Of Epidermal Cells Nuclear Thyroid Hormone Receptor Binding Regulation Of Cell Motility Regulation Of Cell Migration Cell Adhesion Regulation Of Cellular Response To Hypoxia Wound Healing, Spreading Of Cells Negative Regulation Of Hippo Signaling Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Kinase Activator Activity Regulation Of Hippo Signaling Lamellipodium Organization MiRNA-mediated Gene Silencing By Inhibition Of Translation Cytoskeleton Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
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