AJUBA and BCAR1

Number of citations of the paper that reports this interaction (PMID 15728191)
26

Data Source:
HPRD (two hybrid, in vivo)

		AJUBA	BCAR1
Gene Name		ajuba LIM protein	breast cancer anti-estrogen resistance 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Transcription Factor Complex Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Lamellipodium	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Alpha-catenin Binding Actin Filament Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Response To Hypoxia Transcription, DNA-templated Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Complex Assembly Negative Regulation Of Kinase Activity Cellular Protein Localization Gene Silencing By MiRNA Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Regulation Of GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia Positive Regulation Of Gene Silencing By MiRNA	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic	Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328)	Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		10 interactors: ACTA1 AURKAIP1 AURKB BCAR1 CTNNA1 GFI1B GRB2 LATS2 LCK SLC1A2	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		84962	9564
HPRD ID		16426	04248
Ensembl ID		ENSG00000129474	ENSG00000050820
Uniprot IDs		Q96IF1	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs			1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Aging Response To Hormone Response To Wounding Response To Organonitrogen Compound Response To Organic Substance Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Abiotic Stimulus Organ Development Organelle Organization Platelet Activation Cellular Response To Hormone Stimulus Multicellular Organismal Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Developmental Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway System Development Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Costimulation Response To External Stimulus Negative Regulation Of Cell Division Cellular Response To Organic Substance Blood Coagulation Cell Division Regulation Of Cellular Component Organization Hemostasis Response To Radiation Negative Regulation Of Cell Cycle Response To Peptide Hormone Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Skeletal Muscle Fiber Adaptation Negative Regulation Of Integrin-mediated Signaling Pathway Cellular Response To Stimulus Response To Peptide T Cell Receptor Signaling Pathway Anatomical Structure Development Protein Heterooligomerization Histone H3-S28 Phosphorylation D-aspartate Import	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?		belongs carp cdna connect contained cytoplasm cytoskeleton entire extracellular frame gcrv grass hybrid immediately immunoprecipitation inducible ip jx01 lim location matrix ns26 orf overlap polypeptide reading responding sub	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		belongs carp cdna connect contained cytoplasm cytoskeleton entire extracellular frame gcrv grass hybrid immediately immunoprecipitation inducible ip jx01 lim location matrix ns26 orf overlap polypeptide reading responding sub	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?