VIL1 and PLCG1

Number of citations of the paper that reports this interaction (PubMedID 12937273)
50

Data Source:
HPRD (in vitro)

		VIL1	PLCG1
Description		villin 1	phospholipase C gamma 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Actin Cytoskeleton Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Cell Projection Extracellular Exosome	Ruffle Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Metal Ion Binding Calcium-dependent Phospholipase C Activity Phosphatidylinositol Phospholipase C Activity
	Biological Process	Intestinal D-glucose Absorption Apoptotic Process Cytoskeleton Organization Actin Filament Organization Epidermal Growth Factor Receptor Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Microvillus Length Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Cellular Component Biogenesis Actin Filament Severing Barbed-end Actin Filament Capping Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Protein-containing Complex Assembly Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Lamellipodium Organization Terminal Web Assembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Lamellipodium Morphogenesis	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Cell Migration Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Signaling by ALK Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Red blood cell count ( 27863252) Waist-hip index ( 34021172)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: ACTA1 ACTG1 JAK3 PLCG1 RNF10 SRC TEX11	112 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RBM11 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		7429	5335
HPRD ID		01898	01398
Ensembl ID		ENSG00000127831	ENSG00000124181
Uniprot IDs		P09327 Q53F91	P19174
PDB IDs		1UNC 3FG7	1HSQ 2HSP 4EY0 4FBN 7NXE
Enriched GO Terms of Interacting Partners?		Actin Filament Negative Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Epithelial Cell Migration Fc Receptor Signaling Pathway Regulation Of Cell-substrate Junction Organization Basal Body Patch Regulation Of Focal Adhesion Assembly ERBB Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Meiotic Gene Conversion Structural Constituent Of Cytoskeleton ATP Binding Blood Microparticle Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell Migration Response To Peptide Positive Regulation Of Cell Motility Response To Cytokine Actomyosin Structure Organization Multicellular Organismal-level Homeostasis Negative Regulation Of Dendritic Cell Cytokine Production Response To Interleukin-9 Negative Regulation Of Immune System Process Response To Interleukin-2 Response To Interleukin-15 Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Ruffle Membrane Calcium-dependent Phospholipase C Activity Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Gene Conversion Male Meiosis Chromosome Segregation Positive Regulation Of Locomotion Regulation Of Apoptotic Process Regulation Of Transepithelial Transport Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Programmed Cell Death Cellular Response To Progesterone Stimulus Enzyme-linked Receptor Protein Signaling Pathway Nucleotide Binding Lamellipodium Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Protein Localization To Bicellular Tight Junction Structural Constituent Of Postsynaptic Actin Cytoskeleton	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Plasma Membrane Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Cell Migration Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Receptor Complex Antigen Receptor-mediated Signaling Pathway Cell Motility Activation Of Immune Response Immune System Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway ATP Binding Cell Activation Positive Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Growth Factor Developmental Process Nucleotide Binding Leukocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
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