VIL1 and ACTG1

Number of citations of the paper that reports this interaction (PMID 6893424)
121

Data Source:
HPRD (in vitro)

		VIL1	ACTG1
Gene Name		villin 1	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Microvillus Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Protein Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Nucleation Actin Filament Severing Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Lamellipodium Morphogenesis	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACTA1 ACTG1 JAK3 PLCG1 SRC TEX11	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		7429	71
HPRD ID		01898	00017
Ensembl ID			ENSG00000184009
Uniprot IDs		P09327 Q53F91	P63261
PDB IDs		1UNC 3FG7
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Immune Response Phagocytosis Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Anatomical Structure Development Axon Guidance Blood Coagulation Locomotion Hemostasis Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Myofibril Assembly Developmental Process Adherens Junction Organization Axonogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of FasL Biosynthetic Process Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Immune Response Neuron Projection Morphogenesis Actin Filament-based Process Endocytosis Cell Activation Cell Development Response To External Stimulus Response To Wounding Negative Regulation Of Dendritic Cell Cytokine Production Skeletal Muscle Fiber Adaptation	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed visceral	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed visceral	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?