COTL1 and PDE6H

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		COTL1	PDE6H
Description		coactosin like F-actin binding protein 1	phosphodiesterase 6H
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Site Of Polarized Growth Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Photoreceptor Outer Segment Membrane
	Molecular Function	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Regulation Of Actin Filament Polymerization Defense Response To Fungus	Visual Perception Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Neutrophil degranulation
Drugs			Sildenafil Vardenafil
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)
Interacting Genes		6 interacting genes: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP	6 interacting genes: AGTR1 APP COTL1 GNAO1 POU6F2 PRKAB2
Entrez ID		23406	5149
HPRD ID		09482	03116
Ensembl ID		ENSG00000103187	ENSG00000139053
Uniprot IDs		A0A384MTY2 Q14019	Q13956
PDB IDs		1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?		Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Hydrolase Activity Actin Cytoskeleton Platelet Aggregation Morphogenesis Of An Epithelium Homotypic Cell-cell Adhesion Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Tissue Morphogenesis Protein Localization To Cell Junction Regulation Of Double-strand Break Repair Via Homologous Recombination Schaffer Collateral - CA1 Synapse Regulation Of Norepinephrine Uptake Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Arachidonate 8(S)-lipoxygenase Activity Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Response To Stress Cell-cell Junction Assembly Nuclear Matrix Transporter Regulator Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of DNA Recombination Regulation Of Wound Healing Cytoskeleton Extracellular Space Regulation Of Double-strand Break Repair Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Axonogenesis	Regulation Of Blood Circulation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Regulation Of System Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production System Process Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Fungus Response To Fungus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Binding Site Of Polarized Growth G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Small Molecule Metabolic Process Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Positive Regulation Of Inflammatory Response Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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