COTL1

Description		coactosin like F-actin binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Site Of Polarized Growth Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding
	Biological Process	Regulation Of Actin Filament Polymerization Defense Response To Fungus
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)
Novel Interacting Genes		1 novel interacting genes: BBS5
Interacting Genes		6 interacting genes: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP
Entrez ID		23406
HPRD ID		09482
Ensembl ID		ENSG00000103187
Uniprot IDs		A0A384MTY2 Q14019
PDB IDs		1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?		Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Hydrolase Activity Actin Cytoskeleton Platelet Aggregation Morphogenesis Of An Epithelium Homotypic Cell-cell Adhesion Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Tissue Morphogenesis Protein Localization To Cell Junction Regulation Of Double-strand Break Repair Via Homologous Recombination Schaffer Collateral - CA1 Synapse Regulation Of Norepinephrine Uptake Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Arachidonate 8(S)-lipoxygenase Activity Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Response To Stress Cell-cell Junction Assembly Nuclear Matrix Transporter Regulator Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of DNA Recombination Regulation Of Wound Healing Cytoskeleton Extracellular Space Regulation Of Double-strand Break Repair Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Axonogenesis
Tagcloud ?